path(MESH:D000544) decreases bp(GO:"GO:0032455")

PubMed:18986241

Bruno and Cuello reported that a protease cascade which converts proNGF to mature NGF (mNGF) and degrades mNGF in the extracellular space by the coordinated activity of plasminogen, tissue plasminogen activator (tPA), neuroserpin, matrix metalloproteinase (MMP)-9 and tissue inhibitor of MMP (TIMP)-1 may be defective in AD, resulting in NGF dysfunction [74].

MeSH

Cognitive Dysfunction

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