a(CHEBI:"LPS with O-antigen") increases bp(GO:"TRIF-dependent toll-like receptor 4 signaling pathway")

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PubMed:23702978

One checkpoint is that bacterial mRNA from live bacteria (also known as vita-PAMPs)44 activates NLRP3; the other checkpoint is that TLR4- and TRIF (TIR domain-containing adaptor protein inducing IFNβ)-dependent signalling — which is triggered by bacterial lipopolysaccharide (LPS) — mediate the secretion of type I IFNs, inducing pro-caspase 11 expression and activation by triggering the IFNα/β receptor (IFNAR) (FIG. 1).

Related Edges 4

• bp(GO:"TRIF-dependent toll-like receptor 4 signaling pathway") regulates sec(a(MESH:"Interferon Type I"))
• bp(GO:"TRIF-dependent toll-like receptor 4 signaling pathway") increases p(HGNC:SCAF11)
• bp(GO:"TRIF-dependent toll-like receptor 4 signaling pathway") increases act(p(HGNC:IFNAR1))
• act(p(HGNC:IFNAR1)) increases act(p(HGNC:SCAF11))

Confidence

Medium

NeuroMMSigDB

Interferon signaling subgraph

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