p(HGNC:SORT1) association path(MESH:D000544)

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PubMed:18986241

Recent findings indicate that the putative proapoptotic effect(s) of p75NTR-mediated proNGF signaling is dependent on interactions between p75NTR and the neurotensin receptor sortilin, a Vps10p domain trafficking protein that acts as a cell surface coreceptor with p75NTR to mediate proNGF-induced cell death. This family of receptors is acquiring increasing importance owing to its potential involvement in AD [68]. A recent study provided genetic information for a role of the proneurotrophin receptor complex comprising sortilin and p75NTR, in the mediation of neuronal viability in vivo [69]. Sortilin expression is required for p75NTR-mediated apoptosis following proNGF treatment [57], suggesting that sortilin is a p75NTR binding partner associated with the initiation of cell death [51,58]

Related Edges 2

• composite(a(MESHC:"pro-nerve growth factor, human"), complex(p(HGNC:NGFR), p(HGNC:SORT1))) increases bp(GO:"GO:0006915")
• path(MESH:D000544) association p(HGNC:SORT1)

MeSH

Cognitive Dysfunction

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