act(p(HGNC:DRD1)) increases p(HGNC:CDK5)

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PubMed:30061532

Both administration of amphetamines and stimulation of D1R induce a significant increase of CDK5 gene expression and protein levels, which, at molecular level, associates with increased dendritic spine density and hyper-phosphorylation of the cytoskeletal tau protein

Related Edges 7

• a(CHEBI:amphetamine) increases g(HGNC:CDK5)
• a(CHEBI:amphetamine) increases p(HGNC:CDK5)
• a(GO:"dendritic spine") positiveCorrelation p(HGNC:CDK5)
• p(HGNC:CDK5) positiveCorrelation a(GO:"dendritic spine")
• p(HGNC:CDK5) positiveCorrelation p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
• act(p(HGNC:DRD1)) increases g(HGNC:CDK5)
• p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) positiveCorrelation p(HGNC:CDK5)

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