bp(GO:"ERAD pathway") regulates deg(p(HGNC:CFTR))

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PubMed:14556719

It should be noted that CFTR degradation is mediated by Endoplasmic Reticulum Associated Degradation (ERAD—a quality control mechanism that eliminates, via the UPS, misfolded/mutated/abnormal membrane or lumenal ER proteins following their retrotranslocation to the cytosol via the Sec61 translocation channel).

Related Edges 1

• p(HGNC:SEC61A1) increases tloc(p(MESH:Proteins, pmod(HBP:misfolding)), fromLoc(GO:"endoplasmic reticulum lumen"), toLoc(GO:cytosol))

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

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