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bp(GO:"ERAD pathway")

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Entity

Name
ERAD pathway
Namespace
go
Namespace Version
20180921
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/go-names.belns

Appears in Networks 3

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In-Edges 2

complex(p(HGNC:BAG6), p(MESH:Proteins, pmod(HBP:misfolding))) association bp(GO:"ERAD pathway") View Subject | View Object

Specifically, Bag6 recognizes and binds to long hydrophobic stretches of the polypeptide chain of misfolded proteins targeted by the ERAD (endoplasmic reticulum associated protein degradation) pathway [56–58] PubMed:24457024

Appears in Networks:

act(p(HGNC:VCP)) regulates bp(GO:"ERAD pathway") View Subject | View Object

For example, p62, an adaptor protein for autophagy, also influences proteasomal degradation, whereas VCP/p97 acting through p62 and ubiquitin regulates both the proteasome-dependent endoplasmic reticulum–associated degradation (ERAD) pathway and aspects of autophagosome maturation (Tresse et al. 2010). PubMed:22908190

Appears in Networks:

Out-Edges 3

bp(GO:"ERAD pathway") regulates deg(p(HGNC:CFTR)) View Subject | View Object

It should be noted that CFTR degradation is mediated by Endoplasmic Reticulum Associated Degradation (ERAD—a quality control mechanism that eliminates, via the UPS, misfolded/mutated/abnormal membrane or lumenal ER proteins following their retrotranslocation to the cytosol via the Sec61 translocation channel). PubMed:14556719

Appears in Networks:

bp(GO:"ERAD pathway") increases deg(p(HGNC:PRNP, pmod(HBP:misfolding))) View Subject | View Object

Alternatively, if misfolded, it is believed to be directed to degradation via ERAD (Yedidia et al., 2001). PubMed:14556719

Appears in Networks:

bp(GO:"ERAD pathway") association complex(p(HGNC:BAG6), p(MESH:Proteins, pmod(HBP:misfolding))) View Subject | View Object

Specifically, Bag6 recognizes and binds to long hydrophobic stretches of the polypeptide chain of misfolded proteins targeted by the ERAD (endoplasmic reticulum associated protein degradation) pathway [56–58] PubMed:24457024

Appears in Networks:

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.