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p(HGNC:VCP)

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Entity

Name
VCP
Namespace
hgnc
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns

Appears in Networks 2

Perilous journey: a tour of the ubiquitin–proteasome system v1.0.0

The Ubiquitin–Proteasome System and the Autophagic–Lysosomal System in Alzheimer Disease v1.0.0

In-Edges 1

composite(a(MESH:Ubiquitin), p(HGNC:SQSTM1)) increases act(p(HGNC:VCP)) View Subject | View Object

For example, p62, an adaptor protein for autophagy, also influences proteasomal degradation, whereas VCP/p97 acting through p62 and ubiquitin regulates both the proteasome-dependent endoplasmic reticulum–associated degradation (ERAD) pathway and aspects of autophagosome maturation (Tresse et al. 2010). PubMed:22908190

Appears in Networks:

Out-Edges 4

p(HGNC:VCP) increases bp(GO:"proteasomal protein catabolic process") View Subject | View Object

For example, yeast Cdc48 (p97 in mammalian cells) is a conserved multisubunit enzyme that plays a major role in dissociating ubiquitinated proteins from their binding partners to promote their degradation by the proteasome [52] PubMed:24457024

Appears in Networks:

p(HGNC:VCP) increases bp(GO:"protein ubiquitination") View Subject | View Object

Cdc48/p97 generally acts downstream of ubiquitin ligases, although its activity may also promote ubiquitination in some cases; a major challenge is to delineate further the mechanism of action of this multipurpose enzyme PubMed:24457024

Appears in Networks:

act(p(HGNC:VCP)) regulates bp(GO:"ERAD pathway") View Subject | View Object

For example, p62, an adaptor protein for autophagy, also influences proteasomal degradation, whereas VCP/p97 acting through p62 and ubiquitin regulates both the proteasome-dependent endoplasmic reticulum–associated degradation (ERAD) pathway and aspects of autophagosome maturation (Tresse et al. 2010). PubMed:22908190

Appears in Networks:

act(p(HGNC:VCP)) regulates a(GO:autophagosome) View Subject | View Object

For example, p62, an adaptor protein for autophagy, also influences proteasomal degradation, whereas VCP/p97 acting through p62 and ubiquitin regulates both the proteasome-dependent endoplasmic reticulum–associated degradation (ERAD) pathway and aspects of autophagosome maturation (Tresse et al. 2010). PubMed:22908190

Appears in Networks:

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.