act(p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits")) decreases act(a(CHEBI:"N-methyl-4-phenylpyridinium"))

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PubMed:19293145

For example, non-alpha7 nAChRs protect cultured nigral dopaminergic neurons from toxicity induced by 1-methyl-4-phenylpyridinium, a neurotoxin that selectively damages nigrostriatal dopaminergic neurons (Jeyarasasingam et al., 2002), and this effect is not mediated by alpha7 receptors.

Related Edges 2

• a(CHEBI:"N-methyl-4-phenylpyridinium") increases path(HBP:neurotoxicity)
• act(p(HGNC:CHRNA7)) causesNoChange act(a(CHEBI:"N-methyl-4-phenylpyridinium"))

MeSH

Dopaminergic Neurons

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