composite(p(HGNC:MAPK1), p(HGNC:MAPK3)) association bp(GO:memory)

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PubMed:19293145

Which pathway is activated by Abeta depends upon the time of exposure to the amyloid peptide: chronic applications of oligomeric Abeta to hippocampal slice cultures activate the JNK/MAPK pathway but inhibit the ERK/MAPK pathway, whereas short-term applications of Abeta oligomers do not activate JNK (Bell et al., 2004). This may be one of the routes whereby Abeta impairs memory, because ERK-1 and ERK-2 play key roles in the signaling events central to memory (Satoh et al., 2007).

Related Edges 3

• a(HBP:"amyloid-beta oligomers") increases act(p(FPLX:JNK))
• a(HBP:"amyloid-beta oligomers") decreases act(p(FPLX:ERK))
• bp(GO:memory) association composite(p(HGNC:MAPK1), p(HGNC:MAPK3))

MeSH

Hippocampus

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