act(p(HGNC:CHRNA7)) increases a(MESH:Oxygen)

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PubMed:19293145

Nicotinic neuroprotection against non-Abeta toxicity is also mediated largely through alpha7 nAChRs. alpha7 nAChRs protect PC12 cells against ethanol toxicity (Li et al., 1999a) and from cell death associated with serum depletion (Ren et al., 2005); they protect cultured neurons against glutamate-induced excitotoxicity (Kaneko et al., 1997) and hippocampal slices against oxygen and glucose deprivation (Egea et al., 2007) through the activation of alpha7 nAChRs (Rosa et al., 2006).

Related Edges 7

• act(a(CHEBI:"glutamate(2-)")) increases bp(HBP:Excitotoxicity)
• act(a(CHEBI:ethanol)) increases path(HBP:neurotoxicity)
• a(MESH:Serum) decreases bp(GO:"cell death")
• act(p(HGNC:CHRNA7)) decreases act(a(CHEBI:ethanol))
• act(p(HGNC:CHRNA7)) decreases bp(GO:"cell death")
• act(p(HGNC:CHRNA7)) decreases act(a(CHEBI:"glutamate(2-)"))
• act(p(HGNC:CHRNA7)) increases a(CHEBI:glucose)

MeSH

Hippocampus

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

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