a(CHEBI:"iron(2+)") increases a(MESH:"Cell Adhesion Molecules")

View Subject View Object

PubMed:25307023

Thus, by participating in Fenton chemistry, non-transferrin-bound iron (i.e., iron not bound to the physiological iron transport protein, transferrin) causes oxidative damage, cytotoxicity and enhanced endothelial expression of adhesion molecules, thereby enhancing thrombotic risk (Hershko, 2007).

Related Edges 5

• a(CHEBI:"iron(2+)") positiveCorrelation bp(MESH:"Oxidative Stress")
• a(CHEBI:"iron(2+)") positiveCorrelation bp(MESH:"Cytotoxicity, Immunologic")
• a(CHEBI:"iron(2+)") increases path(MESH:Thrombosis)
• bp(MESH:"Cytotoxicity, Immunologic") positiveCorrelation a(CHEBI:"iron(2+)")
• bp(MESH:"Oxidative Stress") positiveCorrelation a(CHEBI:"iron(2+)")

Cell Ontology (CL)

endothelial cell

MeSH

Plasma

MeSH

Urine

MeSH

Anemia, Hemolytic, Autoimmune

Text Location

Review

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

---