complex(p(HGNC:BAG3), p(HGNC:HSPB8)) positiveCorrelation bp(GO:autophagy)

View Subject View Object

PubMed:22020111

Overexpression of the HSPB8-BAG3 complex also stimulates autophagy and facilitates the clearance of mutated aggregation-prone proteins, the accumulation of which characterizes many neurodegenerative disorders such as Alzheimer disease, Parkinson disease, and amyotrophic lateral sclerosis (Seidel et al., 2011).

Related Edges 8

• a(HBP:"protein aggregates") positiveCorrelation path(MESH:"Alzheimer Disease")
• a(HBP:"protein aggregates") positiveCorrelation path(MESH:"Parkinson Disease")
• a(HBP:"protein aggregates") positiveCorrelation path(MESH:"Amyotrophic Lateral Sclerosis")
• bp(GO:autophagy) positiveCorrelation complex(p(HGNC:BAG3), p(HGNC:HSPB8))
• complex(p(HGNC:BAG3), p(HGNC:HSPB8)) increases deg(a(HBP:"protein aggregates"))
• path(MESH:"Alzheimer Disease") positiveCorrelation a(HBP:"protein aggregates")
• path(MESH:"Amyotrophic Lateral Sclerosis") positiveCorrelation a(HBP:"protein aggregates")
• path(MESH:"Parkinson Disease") positiveCorrelation a(HBP:"protein aggregates")

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

---