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  3. PubMed:22020111

PubMed: 22020111

Title
Oxidative stress in health and disease: the therapeutic potential of Nrf2 activation.
Journal
Molecular aspects of medicine
Volume
32
Issue
None
Pages
234-46
Date
2011-08-01
Authors
Bose SK | McCord JM | Gao B | Hybertson BM

Evidence 803725ffa0
JSON

Sulforaphane is often considered a ‘‘gold standard’’ among naturally-occurring Nrf2 activators (Agyeman et al., 2011).

a(CHEBI:sulforaphane) increases act(p(HGNC:NFE2L2)) View Subject | View Object

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Evidence 38b7248e09
JSON

The greatest FImax was observed with Protandim at 135-fold, followed by bardoxolone methyl at 67-fold, dimethyl fumarate at 55-fold, and sulforaphane at 21-fold

a(CHEBI:"dimethyl fumarate") increases act(p(HGNC:NFE2L2)) View Subject | View Object

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a(CHEBI:sulforaphane) increases act(p(HGNC:NFE2L2)) View Subject | View Object

Appears in Networks:

a(PUBCHEM:135316034) increases act(p(HGNC:NFE2L2)) View Subject | View Object

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a(PUBCHEM:400769) increases act(p(HGNC:NFE2L2)) View Subject | View Object

Appears in Networks:

Evidence e0c90382eb
JSON

When compared contemporaneously in the AREc32-based assay, FImax observed was in the order Protandim > bardoxolone methyl > dimethyl fumarate > sulforaphane.

a(CHEBI:"dimethyl fumarate") increases act(p(HGNC:NFE2L2)) View Subject | View Object

Appears in Networks:

a(CHEBI:sulforaphane) increases act(p(HGNC:NFE2L2)) View Subject | View Object

Appears in Networks:

a(PUBCHEM:135316034) increases act(p(HGNC:NFE2L2)) View Subject | View Object

Appears in Networks:

a(PUBCHEM:400769) increases act(p(HGNC:NFE2L2)) View Subject | View Object

Appears in Networks:

Evidence 240377b798
JSON

A recent laboratory study of dimethyl fumarate found that the compound activates Nrf2 in primary astrocytes, but not in the C6 glioma-derived cell line (Wilms et al., 2010), demonstrating that different cells may respond quite differently to Nrf2 activators

a(CHEBI:"dimethyl fumarate") increases act(p(HGNC:NFE2L2)) View Subject | View Object

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Annotations
MeSH
Astrocytes

a(CHEBI:"dimethyl fumarate") causesNoChange act(p(HGNC:NFE2L2)) View Subject | View Object

Appears in Networks:
Annotations
Experimental Factor Ontology (EFO)
C6 cell

Evidence 14431ea13f
JSON

While Protandim, bardoxolone methyl, BG-12, and sulforaphane all have been demonstrated to modify gene expression profiles by activation of Nrf2, they have not been compared side by side, in the same cell line, under identical conditions.

a(CHEBI:"dimethyl fumarate") increases act(p(HGNC:NFE2L2)) View Subject | View Object

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a(CHEBI:sulforaphane) increases act(p(HGNC:NFE2L2)) View Subject | View Object

Appears in Networks:

a(PUBCHEM:135316034) increases act(p(HGNC:NFE2L2)) View Subject | View Object

Appears in Networks:

a(PUBCHEM:400769) increases act(p(HGNC:NFE2L2)) View Subject | View Object

Appears in Networks:

Evidence a3b28c2592
JSON

This antiporter was recently found to be decreased by repeated cocaine exposure, and restoration of the activity prevented cocaine-primed drug seeking behavior in rats (Baker et al., 2003).

a(CHEBI:cocaine) decreases act(p(HGNC:SLC7A11)) View Subject | View Object

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Evidence bd8d215fdc
JSON

SLC7A11, induced 76-fold, encodes a cystine/glutamate antiporter responsible for maintaining extracellular glutamate in the brain, and for importing cystine necessary for glutathione synthesis (Albrecht et al., 2010).

a(CHEBI:cystine) increases a(CHEBI:glutathione) View Subject | View Object

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Annotations
MeSH
Brain

a(PUBCHEM:135316034) increases p(HGNC:SLC7A11) View Subject | View Object

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p(HGNC:SLC7A11) regulates bp(GO:"glutamate homeostasis") View Subject | View Object

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Annotations
MeSH
Brain

p(HGNC:SLC7A11) increases tloc(a(CHEBI:cystine), fromLoc(GO:"extracellular region"), toLoc(GO:intracellular)) View Subject | View Object

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Annotations
MeSH
Brain

Evidence 56511d0e15
JSON

The study also found that resveratrol, a putative activator of SIRT1 (Howitz et al., 2003), inhibited Nrf2-dependent transcription, apparently contradicting earlier reports that resveratrol activates Nrf2 (Chen et al., 2005; Ungvari et al., 2010).

a(CHEBI:resveratrol) increases act(p(HGNC:SIRT1)) View Subject | View Object

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a(CHEBI:resveratrol) decreases act(p(HGNC:NFE2L2)) View Subject | View Object

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Evidence c7897dd8fd
JSON

Overexpression of the HSPB8-BAG3 complex also stimulates autophagy and facilitates the clearance of mutated aggregation-prone proteins, the accumulation of which characterizes many neurodegenerative disorders such as Alzheimer disease, Parkinson disease, and amyotrophic lateral sclerosis (Seidel et al., 2011).

a(HBP:"protein aggregates") positiveCorrelation path(MESH:"Alzheimer Disease") View Subject | View Object

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a(HBP:"protein aggregates") positiveCorrelation path(MESH:"Parkinson Disease") View Subject | View Object

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a(HBP:"protein aggregates") positiveCorrelation path(MESH:"Amyotrophic Lateral Sclerosis") View Subject | View Object

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bp(GO:autophagy) positiveCorrelation complex(p(HGNC:BAG3), p(HGNC:HSPB8)) View Subject | View Object

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complex(p(HGNC:BAG3), p(HGNC:HSPB8)) positiveCorrelation bp(GO:autophagy) View Subject | View Object

Appears in Networks:

complex(p(HGNC:BAG3), p(HGNC:HSPB8)) increases deg(a(HBP:"protein aggregates")) View Subject | View Object

Appears in Networks:

path(MESH:"Alzheimer Disease") positiveCorrelation a(HBP:"protein aggregates") View Subject | View Object

Appears in Networks:

path(MESH:"Amyotrophic Lateral Sclerosis") positiveCorrelation a(HBP:"protein aggregates") View Subject | View Object

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path(MESH:"Parkinson Disease") positiveCorrelation a(HBP:"protein aggregates") View Subject | View Object

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Evidence 9bd002ea7f
JSON

TNFSF9 (aka CD137L), induced 19-fold, can induce maturation of human immature monocyte-derived dendritic cells leading to an enhanced capacity of the dendritic cells to stimulate protective T cell responses, as compared to classical dendritic cells (Tang et al., 2011).

act(a(MESH:"Dendritic Cells")) increases bp(GO:"T cell activation") View Subject | View Object

Appears in Networks:

a(PUBCHEM:135316034) increases p(HGNC:TNFSF9) View Subject | View Object

Appears in Networks:

p(HGNC:TNFSF9) increases act(a(MESH:"Dendritic Cells")) View Subject | View Object

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p(HGNC:TNFSF9) increases bp(GO:"T cell activation") View Subject | View Object

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Evidence 2792fe6fee
JSON

In Alzheimer disease, 66 genes were identified that are also modulated by Protandim at the gene expression level. Of these 66 genes, the first 43 of them (65%) were regulated by Protandim in the opposing direction to that taken by the Alzheimer disease process. The beneficial effect of Protandim is further supported by the fact that of the 10 gene products currently targeted by drug therapies, eight of them are modulated by Protandim in the same direction that is proposed to be beneficial and caused by the drug.

a(PUBCHEM:135316034) increases p(HGNC:NFE2L2) View Subject | View Object

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Annotations
MeSH
Alzheimer Disease

a(PUBCHEM:135316034) increases p(HGNC:HMOX1) View Subject | View Object

Appears in Networks:
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MeSH
Alzheimer Disease

a(PUBCHEM:135316034) decreases p(HGNC:PTGS1) View Subject | View Object

Appears in Networks:
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MeSH
Alzheimer Disease

a(PUBCHEM:135316034) decreases p(HGNC:TUBB3) View Subject | View Object

Appears in Networks:
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MeSH
Alzheimer Disease

a(PUBCHEM:135316034) increases p(HGNC:NR3C1) View Subject | View Object

Appears in Networks:
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MeSH
Alzheimer Disease

a(PUBCHEM:135316034) increases p(HGNC:PPARA) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

a(PUBCHEM:135316034) increases p(HGNC:PTGS2) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

a(PUBCHEM:135316034) decreases p(HGNC:ACLY) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

a(PUBCHEM:135316034) decreases p(HGNC:TUBB) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

a(PUBCHEM:135316034) decreases p(HGNC:UNG) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

a(PUBCHEM:135316034) increases p(HGNC:NQO1) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

a(PUBCHEM:135316034) decreases p(HGNC:AGRN) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

a(PUBCHEM:135316034) decreases p(HGNC:ANP32A) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

a(PUBCHEM:135316034) decreases p(HGNC:BAX) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

a(PUBCHEM:135316034) decreases p(HGNC:BCHE) View Subject | View Object

Appears in Networks:
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MeSH
Alzheimer Disease

a(PUBCHEM:135316034) decreases p(HGNC:BGN) View Subject | View Object

Appears in Networks:
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MeSH
Alzheimer Disease

a(PUBCHEM:135316034) decreases p(HGNC:BRCA1) View Subject | View Object

Appears in Networks:
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MeSH
Alzheimer Disease

a(PUBCHEM:135316034) decreases p(HGNC:CADPS2) View Subject | View Object

Appears in Networks:
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MeSH
Alzheimer Disease

a(PUBCHEM:135316034) decreases p(HGNC:CAPN1) View Subject | View Object

Appears in Networks:
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MeSH
Alzheimer Disease

a(PUBCHEM:135316034) decreases p(HGNC:CCNB1) View Subject | View Object

Appears in Networks:
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MeSH
Alzheimer Disease

a(PUBCHEM:135316034) decreases p(HGNC:CDK1) View Subject | View Object

Appears in Networks:
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MeSH
Alzheimer Disease

a(PUBCHEM:135316034) decreases p(HGNC:CDK2) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

a(PUBCHEM:135316034) decreases p(HGNC:CDKN2A) View Subject | View Object

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MeSH
Alzheimer Disease

a(PUBCHEM:135316034) decreases p(HGNC:CXCR4) View Subject | View Object

Appears in Networks:
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MeSH
Alzheimer Disease

a(PUBCHEM:135316034) decreases p(HGNC:EIF4EBP1) View Subject | View Object

Appears in Networks:
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MeSH
Alzheimer Disease

a(PUBCHEM:135316034) decreases p(HGNC:FOLH1) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

a(PUBCHEM:135316034) decreases p(HGNC:HOMER1) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

a(PUBCHEM:135316034) decreases p(HGNC:HRH1) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

a(PUBCHEM:135316034) decreases p(HGNC:IGF2) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

a(PUBCHEM:135316034) decreases p(HGNC:IGFBP2) View Subject | View Object

Appears in Networks:
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MeSH
Alzheimer Disease

a(PUBCHEM:135316034) decreases p(HGNC:LDLR) View Subject | View Object

Appears in Networks:
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MeSH
Alzheimer Disease

a(PUBCHEM:135316034) decreases p(HGNC:MAOA) View Subject | View Object

Appears in Networks:
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MeSH
Alzheimer Disease

a(PUBCHEM:135316034) decreases p(HGNC:NEFH) View Subject | View Object

Appears in Networks:
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MeSH
Alzheimer Disease

a(PUBCHEM:135316034) decreases p(HGNC:NPDC1) View Subject | View Object

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MeSH
Alzheimer Disease

a(PUBCHEM:135316034) decreases p(HGNC:NRGN) View Subject | View Object

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MeSH
Alzheimer Disease

a(PUBCHEM:135316034) decreases p(HGNC:PREP) View Subject | View Object

Appears in Networks:
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MeSH
Alzheimer Disease

a(PUBCHEM:135316034) decreases p(HGNC:PROS1) View Subject | View Object

Appears in Networks:
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MeSH
Alzheimer Disease

a(PUBCHEM:135316034) decreases p(HGNC:SELENBP1) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

a(PUBCHEM:135316034) decreases p(HGNC:TAGLN) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

a(PUBCHEM:135316034) decreases p(HGNC:TGFB1) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

a(PUBCHEM:135316034) decreases p(HGNC:VKORC1) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

a(PUBCHEM:135316034) increases p(HGNC:CANX) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

a(PUBCHEM:135316034) increases p(HGNC:GCNT2) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

a(PUBCHEM:135316034) increases p(HGNC:IDE) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

a(PUBCHEM:135316034) increases p(HGNC:MMP1) View Subject | View Object

Appears in Networks:
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MeSH
Alzheimer Disease

a(PUBCHEM:135316034) increases p(HGNC:SLC6A6) View Subject | View Object

Appears in Networks:
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MeSH
Alzheimer Disease

a(PUBCHEM:135316034) increases p(HGNC:SYVN1) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

a(PUBCHEM:135316034) increases p(HGNC:TSHZ1) View Subject | View Object

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MeSH
Alzheimer Disease

a(PUBCHEM:135316034) increases p(HGNC:TXN) View Subject | View Object

Appears in Networks:
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MeSH
Alzheimer Disease

a(PUBCHEM:135316034) decreases p(HGNC:ATAD2) View Subject | View Object

Appears in Networks:
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MeSH
Alzheimer Disease

a(PUBCHEM:135316034) decreases p(HGNC:BECN1) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

a(PUBCHEM:135316034) decreases p(HGNC:DHCR24) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

a(PUBCHEM:135316034) decreases p(HGNC:FGF2) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

a(PUBCHEM:135316034) decreases p(HGNC:HTRA1) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

a(PUBCHEM:135316034) decreases p(HGNC:PRKCE) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

a(PUBCHEM:135316034) decreases p(HGNC:PRKDC) View Subject | View Object

Appears in Networks:
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MeSH
Alzheimer Disease

a(PUBCHEM:135316034) decreases p(HGNC:SCD) View Subject | View Object

Appears in Networks:
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MeSH
Alzheimer Disease

a(PUBCHEM:135316034) increases p(HGNC:ATP1A1) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

a(PUBCHEM:135316034) increases p(HGNC:CTSD) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

a(PUBCHEM:135316034) increases p(HGNC:GLRX) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

a(PUBCHEM:135316034) increases p(HGNC:IL6R) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

a(PUBCHEM:135316034) increases p(HGNC:NPTX1) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

a(PUBCHEM:135316034) increases p(HGNC:PHF1) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

a(PUBCHEM:135316034) increases p(HGNC:PRKCD) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

a(PUBCHEM:135316034) increases p(HGNC:RANBP9) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

a(PUBCHEM:135316034) increases p(HGNC:SOD1) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

path(MESH:"Alzheimer Disease") increases p(HGNC:AGRN) View Subject | View Object

Appears in Networks:

path(MESH:"Alzheimer Disease") increases p(HGNC:ANP32A) View Subject | View Object

Appears in Networks:

path(MESH:"Alzheimer Disease") increases p(HGNC:BAX) View Subject | View Object

Appears in Networks:

path(MESH:"Alzheimer Disease") increases p(HGNC:BCHE) View Subject | View Object

Appears in Networks:

path(MESH:"Alzheimer Disease") increases p(HGNC:BGN) View Subject | View Object

Appears in Networks:

path(MESH:"Alzheimer Disease") increases p(HGNC:BRCA1) View Subject | View Object

Appears in Networks:

path(MESH:"Alzheimer Disease") increases p(HGNC:CADPS2) View Subject | View Object

Appears in Networks:

path(MESH:"Alzheimer Disease") increases p(HGNC:CAPN1) View Subject | View Object

Appears in Networks:

path(MESH:"Alzheimer Disease") increases p(HGNC:CCNB1) View Subject | View Object

Appears in Networks:

path(MESH:"Alzheimer Disease") increases p(HGNC:CDK1) View Subject | View Object

Appears in Networks:

path(MESH:"Alzheimer Disease") increases p(HGNC:CDK2) View Subject | View Object

Appears in Networks:

path(MESH:"Alzheimer Disease") increases p(HGNC:CDKN2A) View Subject | View Object

Appears in Networks:

path(MESH:"Alzheimer Disease") increases p(HGNC:CXCR4) View Subject | View Object

Appears in Networks:

path(MESH:"Alzheimer Disease") increases p(HGNC:EIF4EBP1) View Subject | View Object

Appears in Networks:

path(MESH:"Alzheimer Disease") increases p(HGNC:FOLH1) View Subject | View Object

Appears in Networks:

path(MESH:"Alzheimer Disease") increases p(HGNC:HOMER1) View Subject | View Object

Appears in Networks:

path(MESH:"Alzheimer Disease") increases p(HGNC:HRH1) View Subject | View Object

Appears in Networks:

path(MESH:"Alzheimer Disease") increases p(HGNC:IGF2) View Subject | View Object

Appears in Networks:

path(MESH:"Alzheimer Disease") increases p(HGNC:IGFBP2) View Subject | View Object

Appears in Networks:

path(MESH:"Alzheimer Disease") increases p(HGNC:LDLR) View Subject | View Object

Appears in Networks:

path(MESH:"Alzheimer Disease") increases p(HGNC:MAOA) View Subject | View Object

Appears in Networks:

path(MESH:"Alzheimer Disease") increases p(HGNC:NEFH) View Subject | View Object

Appears in Networks:

path(MESH:"Alzheimer Disease") increases p(HGNC:NPDC1) View Subject | View Object

Appears in Networks:

path(MESH:"Alzheimer Disease") increases p(HGNC:NRGN) View Subject | View Object

Appears in Networks:

path(MESH:"Alzheimer Disease") increases p(HGNC:PREP) View Subject | View Object

Appears in Networks:

path(MESH:"Alzheimer Disease") increases p(HGNC:PROS1) View Subject | View Object

Appears in Networks:

path(MESH:"Alzheimer Disease") increases p(HGNC:PTGS1) View Subject | View Object

Appears in Networks:

path(MESH:"Alzheimer Disease") increases p(HGNC:SELENBP1) View Subject | View Object

Appears in Networks:

path(MESH:"Alzheimer Disease") increases p(HGNC:TAGLN) View Subject | View Object

Appears in Networks:

path(MESH:"Alzheimer Disease") increases p(HGNC:TGFB1) View Subject | View Object

Appears in Networks:

path(MESH:"Alzheimer Disease") increases p(HGNC:TUBB3) View Subject | View Object

Appears in Networks:

path(MESH:"Alzheimer Disease") increases p(HGNC:VKORC1) View Subject | View Object

Appears in Networks:

path(MESH:"Alzheimer Disease") decreases p(HGNC:CANX) View Subject | View Object

Appears in Networks:

path(MESH:"Alzheimer Disease") decreases p(HGNC:GCNT2) View Subject | View Object

Appears in Networks:

path(MESH:"Alzheimer Disease") decreases p(HGNC:IDE) View Subject | View Object

Appears in Networks:

path(MESH:"Alzheimer Disease") decreases p(HGNC:MMP1) View Subject | View Object

Appears in Networks:

path(MESH:"Alzheimer Disease") decreases p(HGNC:NFE2L2) View Subject | View Object

Appears in Networks:

path(MESH:"Alzheimer Disease") decreases p(HGNC:NR3C1) View Subject | View Object

Appears in Networks:

path(MESH:"Alzheimer Disease") decreases p(HGNC:PPARA) View Subject | View Object

Appears in Networks:

path(MESH:"Alzheimer Disease") decreases p(HGNC:SLC6A6) View Subject | View Object

Appears in Networks:

path(MESH:"Alzheimer Disease") decreases p(HGNC:SYVN1) View Subject | View Object

Appears in Networks:

path(MESH:"Alzheimer Disease") decreases p(HGNC:TSHZ1) View Subject | View Object

Appears in Networks:

path(MESH:"Alzheimer Disease") decreases p(HGNC:TXN) View Subject | View Object

Appears in Networks:

path(MESH:"Alzheimer Disease") decreases p(HGNC:ACLY) View Subject | View Object

Appears in Networks:

path(MESH:"Alzheimer Disease") decreases p(HGNC:ATAD2) View Subject | View Object

Appears in Networks:

path(MESH:"Alzheimer Disease") decreases p(HGNC:BECN1) View Subject | View Object

Appears in Networks:

path(MESH:"Alzheimer Disease") decreases p(HGNC:DHCR24) View Subject | View Object

Appears in Networks:

path(MESH:"Alzheimer Disease") decreases p(HGNC:FGF2) View Subject | View Object

Appears in Networks:

path(MESH:"Alzheimer Disease") decreases p(HGNC:HTRA1) View Subject | View Object

Appears in Networks:

path(MESH:"Alzheimer Disease") decreases p(HGNC:PRKCE) View Subject | View Object

Appears in Networks:

path(MESH:"Alzheimer Disease") decreases p(HGNC:PRKDC) View Subject | View Object

Appears in Networks:

path(MESH:"Alzheimer Disease") decreases p(HGNC:SCD) View Subject | View Object

Appears in Networks:

path(MESH:"Alzheimer Disease") decreases p(HGNC:TUBB) View Subject | View Object

Appears in Networks:

path(MESH:"Alzheimer Disease") decreases p(HGNC:UNG) View Subject | View Object

Appears in Networks:

path(MESH:"Alzheimer Disease") increases p(HGNC:ATP1A1) View Subject | View Object

Appears in Networks:

path(MESH:"Alzheimer Disease") increases p(HGNC:CTSD) View Subject | View Object

Appears in Networks:

path(MESH:"Alzheimer Disease") increases p(HGNC:GLRX) View Subject | View Object

Appears in Networks:

path(MESH:"Alzheimer Disease") increases p(HGNC:HMOX1) View Subject | View Object

Appears in Networks:

path(MESH:"Alzheimer Disease") increases p(HGNC:IL6R) View Subject | View Object

Appears in Networks:

path(MESH:"Alzheimer Disease") increases p(HGNC:NPTX1) View Subject | View Object

Appears in Networks:

path(MESH:"Alzheimer Disease") increases p(HGNC:NQO1) View Subject | View Object

Appears in Networks:

path(MESH:"Alzheimer Disease") increases p(HGNC:PHF1) View Subject | View Object

Appears in Networks:

path(MESH:"Alzheimer Disease") increases p(HGNC:PRKCD) View Subject | View Object

Appears in Networks:

path(MESH:"Alzheimer Disease") increases p(HGNC:PTGS2) View Subject | View Object

Appears in Networks:

path(MESH:"Alzheimer Disease") increases p(HGNC:RANBP9) View Subject | View Object

Appears in Networks:

path(MESH:"Alzheimer Disease") increases p(HGNC:SOD1) View Subject | View Object

Appears in Networks:

Evidence 8883796664
JSON

In our gene expression data, SIRT1 was induced 1.75-fold by Protandim (p = 0.015).

a(PUBCHEM:135316034) increases p(HGNC:SIRT1) View Subject | View Object

Appears in Networks:

Evidence 35da14e46a
JSON

AKR1B10, induced 72-fold, encodes aldo–keto reductase family 1 member B10 which efficiently detoxifies mutagenic and carcinogenic alpha, beta-unsaturated carbonyls such as 4-hydroxynonenal (Zhong et al., 2009).

a(PUBCHEM:135316034) increases p(HGNC:AKR1B10) View Subject | View Object

Appears in Networks:

p(HGNC:AKR1B10) increases bp(GO:detoxification) View Subject | View Object

Appears in Networks:

p(HGNC:AKR1B10) decreases a(PUBCHEM:5283344) View Subject | View Object

Appears in Networks:

Evidence d06a86a2ac
JSON

PTGR1 (aka LTB4DH), induced 68-fold, encodes leukotriene B4-12-hydroxydehydrogenase, which is considered to be a key enzyme responsible for biological inactivation of prostaglandins and related eicosanoids (Tai et al., 2002).

a(PUBCHEM:135316034) increases p(HGNC:PTGR1) View Subject | View Object

Appears in Networks:

p(HGNC:PTGR1) decreases act(a(MESH:Prostaglandins)) View Subject | View Object

Appears in Networks:

p(HGNC:PTGR1) decreases act(a(MESH:Eicosanoids)) View Subject | View Object

Appears in Networks:

Evidence f9dbfcaf87
JSON

HMOX1, induced 56-fold, encodes heme oxygenase-1, an antioxidant enzyme considered a hallmark of Nrf2 activation.

a(PUBCHEM:135316034) increases p(HGNC:HMOX1) View Subject | View Object

Appears in Networks:

p(HGNC:HMOX1) increases act(p(HGNC:NFE2L2)) View Subject | View Object

Appears in Networks:

Evidence 569eaa9419
JSON

A likely explanation for the increased expression of GLRX2 (glutaredoxin 2) and NQO1 (NAD(P)H dehydrogenase, quinone 1) in colon carcinoma and of GLRX (glutaredoxin), HMOX1 (heme oxygenase-1), NQO1, and SOD1 (superoxide dismutase 1) in Alzheimer is that it represents an adaptive attempt to partially compensate for the increased level of oxidative stress associated with these diseases. These antioxidant genes are also upregulated by Protandim, which would provide additional antioxidant protection beyond that achieved by the ROS-dependent induction of these enzymes in the diseased tissues.

a(PUBCHEM:135316034) increases p(HGNC:HMOX1) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

a(PUBCHEM:135316034) increases p(HGNC:GLRX2) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Colorectal Neoplasms

a(PUBCHEM:135316034) increases p(HGNC:NQO1) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Colorectal Neoplasms

a(PUBCHEM:135316034) increases p(HGNC:GLRX) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

a(PUBCHEM:135316034) increases p(HGNC:SOD1) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

bp(MESH:"Oxidative Stress") positiveCorrelation path(MESH:"Colorectal Neoplasms") View Subject | View Object

Appears in Networks:

bp(MESH:"Oxidative Stress") positiveCorrelation path(MESH:"Alzheimer Disease") View Subject | View Object

Appears in Networks:

p(HGNC:GLRX) positiveCorrelation path(MESH:"Alzheimer Disease") View Subject | View Object

Appears in Networks:

p(HGNC:GLRX2) positiveCorrelation path(MESH:"Colorectal Neoplasms") View Subject | View Object

Appears in Networks:

p(HGNC:HMOX1) positiveCorrelation path(MESH:"Alzheimer Disease") View Subject | View Object

Appears in Networks:

p(HGNC:NQO1) positiveCorrelation path(MESH:"Colorectal Neoplasms") View Subject | View Object

Appears in Networks:

p(HGNC:NQO1) positiveCorrelation path(MESH:"Alzheimer Disease") View Subject | View Object

Appears in Networks:

p(HGNC:SOD1) positiveCorrelation path(MESH:"Alzheimer Disease") View Subject | View Object

Appears in Networks:

path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:GLRX) View Subject | View Object

Appears in Networks:

path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:HMOX1) View Subject | View Object

Appears in Networks:

path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:NQO1) View Subject | View Object

Appears in Networks:

path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:SOD1) View Subject | View Object

Appears in Networks:

path(MESH:"Alzheimer Disease") positiveCorrelation bp(MESH:"Oxidative Stress") View Subject | View Object

Appears in Networks:

path(MESH:"Colorectal Neoplasms") positiveCorrelation p(HGNC:GLRX2) View Subject | View Object

Appears in Networks:

path(MESH:"Colorectal Neoplasms") positiveCorrelation p(HGNC:NQO1) View Subject | View Object

Appears in Networks:

path(MESH:"Colorectal Neoplasms") positiveCorrelation bp(MESH:"Oxidative Stress") View Subject | View Object

Appears in Networks:

Evidence 14db65e12f
JSON

AIFM2 (aka AMID), induced 29-fold, is implicated in caspase-independent apoptosis and was found to be downregulated in a majority of human tumors (Wu et al., 2004b).

a(PUBCHEM:135316034) increases p(HGNC:AIFM2) View Subject | View Object

Appears in Networks:

p(HGNC:AIFM2) negativeCorrelation path(MESH:Neoplasms) View Subject | View Object

Appears in Networks:

path(MESH:Neoplasms) negativeCorrelation p(HGNC:AIFM2) View Subject | View Object

Appears in Networks:

Evidence 32f98f3b9d
JSON

OSGIN1 (aka OKL38), induced 29-fold, is an oxidative stress response gene and a tumor suppressor gene (Yao et al., 2008).

a(PUBCHEM:135316034) increases p(HGNC:OSGIN1) View Subject | View Object

Appears in Networks:

Evidence dcf7aef963
JSON

GPX3, induced 20-fold, encodes an important antioxidant enzyme, glutathione peroxidase-3, found normally in plasma and kidney but underexpressed in head and neck cancers (Chen et al., 2011).

a(PUBCHEM:135316034) increases p(HGNC:GPX3) View Subject | View Object

Appears in Networks:

p(HGNC:GPX3) negativeCorrelation path(MESH:Neoplasms) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Head
MeSH
Neck

path(MESH:Neoplasms) negativeCorrelation p(HGNC:GPX3) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Head
MeSH
Neck

Evidence a33a8e981a
JSON

SQSTM1, induced 20-fold, encodes sequestosome-1, a participant in the autophagy pathway recently shown to be necessary to avoid premature senescence in human fibroblasts (Kang et al., 2011).

a(PUBCHEM:135316034) increases p(HGNC:SQSTM1) View Subject | View Object

Appears in Networks:

p(HGNC:SQSTM1) increases bp(GO:autophagy) View Subject | View Object

Appears in Networks:

p(HGNC:SQSTM1) decreases bp(GO:"stress-induced premature senescence") View Subject | View Object

Appears in Networks:
Annotations
MeSH
Fibroblasts

Evidence 1071232bfe
JSON

HSPB8, induced 19-fold, is a heat shock protein that forms a complex with BAG3 (also induced 1.43-fold).

a(PUBCHEM:135316034) increases p(HGNC:HSPB8) View Subject | View Object

Appears in Networks:

p(HGNC:HSPB8) increases complex(p(HGNC:BAG3), p(HGNC:HSPB8)) View Subject | View Object

Appears in Networks:

Evidence 0868039528
JSON

For example, 19 genes products have been associated with atherosclerosis and are up or down-regulated by Protandim. Of these 19 genes, the first 16 listed (84%) were regulated by Protandim in the opposing direction to that taken by the atherosclerosis disease process. The probable benefit of this effect of Protandim is further supported by the fact that of the 11 gene products currently being targeted by drug interventions (Table 1, in bold type), nine of them (Table 1, marked by asterisks) are modulated by Protandim in the same direction that is proposed to be beneficial and caused by the therapeutic intervention.

a(PUBCHEM:135316034) decreases p(HGNC:CTNNB1) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Atherosclerosis

a(PUBCHEM:135316034) decreases p(HGNC:DHFR) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Atherosclerosis

a(PUBCHEM:135316034) decreases p(HGNC:EDN1) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Atherosclerosis

a(PUBCHEM:135316034) decreases p(HGNC:ITGB3) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Atherosclerosis

a(PUBCHEM:135316034) decreases p(HGNC:MKI67) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Atherosclerosis

a(PUBCHEM:135316034) decreases p(HGNC:MMP11) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Atherosclerosis

a(PUBCHEM:135316034) decreases p(HGNC:MMP14) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Atherosclerosis

a(PUBCHEM:135316034) decreases p(HGNC:MMP2) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Atherosclerosis

a(PUBCHEM:135316034) decreases p(HGNC:PDE7A) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Atherosclerosis

a(PUBCHEM:135316034) decreases p(HGNC:PDE7B) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Atherosclerosis

a(PUBCHEM:135316034) decreases p(HGNC:PLAU) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Atherosclerosis

a(PUBCHEM:135316034) decreases p(HGNC:PTGS1) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Atherosclerosis

a(PUBCHEM:135316034) decreases p(HGNC:SCARB1) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Atherosclerosis

a(PUBCHEM:135316034) decreases p(HGNC:TUBB3) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Atherosclerosis

a(PUBCHEM:135316034) increases p(HGNC:NR3C1) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Atherosclerosis

a(PUBCHEM:135316034) increases p(HGNC:PPARA) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Atherosclerosis

a(PUBCHEM:135316034) increases p(HGNC:EGR1) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Atherosclerosis

a(PUBCHEM:135316034) increases p(HGNC:PTGS2) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Atherosclerosis

a(PUBCHEM:135316034) increases p(HGNC:SOAT1) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Atherosclerosis

path(MESH:Atherosclerosis) increases p(HGNC:CTNNB1) View Subject | View Object

Appears in Networks:

path(MESH:Atherosclerosis) increases p(HGNC:DHFR) View Subject | View Object

Appears in Networks:

path(MESH:Atherosclerosis) increases p(HGNC:EDN1) View Subject | View Object

Appears in Networks:

path(MESH:Atherosclerosis) increases p(HGNC:ITGB3) View Subject | View Object

Appears in Networks:

path(MESH:Atherosclerosis) increases p(HGNC:MKI67) View Subject | View Object

Appears in Networks:

path(MESH:Atherosclerosis) increases p(HGNC:MMP11) View Subject | View Object

Appears in Networks:

path(MESH:Atherosclerosis) increases p(HGNC:MMP14) View Subject | View Object

Appears in Networks:

path(MESH:Atherosclerosis) increases p(HGNC:MMP2) View Subject | View Object

Appears in Networks:

path(MESH:Atherosclerosis) increases p(HGNC:PDE7A) View Subject | View Object

Appears in Networks:

path(MESH:Atherosclerosis) increases p(HGNC:PDE7B) View Subject | View Object

Appears in Networks:

path(MESH:Atherosclerosis) increases p(HGNC:PLAU) View Subject | View Object

Appears in Networks:

path(MESH:Atherosclerosis) increases p(HGNC:PTGS1) View Subject | View Object

Appears in Networks:

path(MESH:Atherosclerosis) increases p(HGNC:SCARB1) View Subject | View Object

Appears in Networks:

path(MESH:Atherosclerosis) increases p(HGNC:TUBB3) View Subject | View Object

Appears in Networks:

path(MESH:Atherosclerosis) decreases p(HGNC:NR3C1) View Subject | View Object

Appears in Networks:

path(MESH:Atherosclerosis) decreases p(HGNC:PPARA) View Subject | View Object

Appears in Networks:

path(MESH:Atherosclerosis) increases p(HGNC:EGR1) View Subject | View Object

Appears in Networks:

path(MESH:Atherosclerosis) increases p(HGNC:PTGS2) View Subject | View Object

Appears in Networks:

path(MESH:Atherosclerosis) increases p(HGNC:SOAT1) View Subject | View Object

Appears in Networks:

Evidence 23d09fa8eb
JSON

In colon carcinoma, IPA analysis revealed 28 genes associated with the disease that were also modulated by Protandim treatment. Of these, the first 25 listed (89%) were regulated by Protandim in the opposing direction to that taken by the colon carcinoma disease process.

a(PUBCHEM:135316034) decreases p(HGNC:DHFR) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Colorectal Neoplasms

a(PUBCHEM:135316034) decreases p(HGNC:TUBB3) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Colorectal Neoplasms

a(PUBCHEM:135316034) decreases p(HGNC:ACLY) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Colorectal Neoplasms

a(PUBCHEM:135316034) decreases p(HGNC:ANTXR1) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Colorectal Neoplasms

a(PUBCHEM:135316034) decreases p(HGNC:C20orf27) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Colorectal Neoplasms

a(PUBCHEM:135316034) decreases p(HGNC:CCNA2) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Colorectal Neoplasms

a(PUBCHEM:135316034) decreases p(HGNC:CHAF1A) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Colorectal Neoplasms

a(PUBCHEM:135316034) decreases p(HGNC:EFCAB11) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Colorectal Neoplasms

a(PUBCHEM:135316034) decreases p(HGNC:FEN1) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Colorectal Neoplasms

a(PUBCHEM:135316034) decreases p(HGNC:GINS2) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Colorectal Neoplasms

a(PUBCHEM:135316034) decreases p(HGNC:MCM10) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Colorectal Neoplasms

a(PUBCHEM:135316034) decreases p(HGNC:MCM4) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Colorectal Neoplasms

a(PUBCHEM:135316034) decreases p(HGNC:RNASEH2A) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Colorectal Neoplasms

a(PUBCHEM:135316034) decreases p(HGNC:SLIT2) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Colorectal Neoplasms

a(PUBCHEM:135316034) decreases p(HGNC:SPC25) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Colorectal Neoplasms

a(PUBCHEM:135316034) decreases p(HGNC:TFRC) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Colorectal Neoplasms

a(PUBCHEM:135316034) decreases p(HGNC:TK1) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Colorectal Neoplasms

a(PUBCHEM:135316034) decreases p(HGNC:TMEM97) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Colorectal Neoplasms

a(PUBCHEM:135316034) decreases p(HGNC:TRIP13) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Colorectal Neoplasms

a(PUBCHEM:135316034) decreases p(HGNC:TUBB) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Colorectal Neoplasms

a(PUBCHEM:135316034) decreases p(HGNC:TYMS) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Colorectal Neoplasms

a(PUBCHEM:135316034) decreases p(HGNC:UBA1) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Colorectal Neoplasms

a(PUBCHEM:135316034) decreases p(HGNC:UNG) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Colorectal Neoplasms

a(PUBCHEM:135316034) decreases p(HGNC:VRK1) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Colorectal Neoplasms

a(PUBCHEM:135316034) increases p(HGNC:ABCD3) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Colorectal Neoplasms

a(PUBCHEM:135316034) increases p(HGNC:GLRX2) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Colorectal Neoplasms

a(PUBCHEM:135316034) increases p(HGNC:MICB) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Colorectal Neoplasms

a(PUBCHEM:135316034) increases p(HGNC:NQO1) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Colorectal Neoplasms

path(MESH:"Colorectal Neoplasms") increases p(HGNC:C20orf27) View Subject | View Object

Appears in Networks:

path(MESH:"Colorectal Neoplasms") increases p(HGNC:CCNA2) View Subject | View Object

Appears in Networks:

path(MESH:"Colorectal Neoplasms") increases p(HGNC:CHAF1A) View Subject | View Object

Appears in Networks:

path(MESH:"Colorectal Neoplasms") increases p(HGNC:DHFR) View Subject | View Object

Appears in Networks:

path(MESH:"Colorectal Neoplasms") increases p(HGNC:EFCAB11) View Subject | View Object

Appears in Networks:

path(MESH:"Colorectal Neoplasms") increases p(HGNC:FEN1) View Subject | View Object

Appears in Networks:

path(MESH:"Colorectal Neoplasms") increases p(HGNC:GINS2) View Subject | View Object

Appears in Networks:

path(MESH:"Colorectal Neoplasms") increases p(HGNC:MCM10) View Subject | View Object

Appears in Networks:

path(MESH:"Colorectal Neoplasms") increases p(HGNC:MCM4) View Subject | View Object

Appears in Networks:

path(MESH:"Colorectal Neoplasms") increases p(HGNC:RNASEH2A) View Subject | View Object

Appears in Networks:

path(MESH:"Colorectal Neoplasms") increases p(HGNC:SLIT2) View Subject | View Object

Appears in Networks:

path(MESH:"Colorectal Neoplasms") increases p(HGNC:SPC25) View Subject | View Object

Appears in Networks:

path(MESH:"Colorectal Neoplasms") increases p(HGNC:ACLY) View Subject | View Object

Appears in Networks:

path(MESH:"Colorectal Neoplasms") increases p(HGNC:ANTXR1) View Subject | View Object

Appears in Networks:

path(MESH:"Colorectal Neoplasms") increases p(HGNC:TFRC) View Subject | View Object

Appears in Networks:

path(MESH:"Colorectal Neoplasms") increases p(HGNC:TK1) View Subject | View Object

Appears in Networks:

path(MESH:"Colorectal Neoplasms") increases p(HGNC:TMEM97) View Subject | View Object

Appears in Networks:

path(MESH:"Colorectal Neoplasms") increases p(HGNC:TRIP13) View Subject | View Object

Appears in Networks:

path(MESH:"Colorectal Neoplasms") increases p(HGNC:TUBB) View Subject | View Object

Appears in Networks:

path(MESH:"Colorectal Neoplasms") increases p(HGNC:TUBB3) View Subject | View Object

Appears in Networks:

path(MESH:"Colorectal Neoplasms") increases p(HGNC:TYMS) View Subject | View Object

Appears in Networks:

path(MESH:"Colorectal Neoplasms") increases p(HGNC:UBA1) View Subject | View Object

Appears in Networks:

path(MESH:"Colorectal Neoplasms") increases p(HGNC:UNG) View Subject | View Object

Appears in Networks:

path(MESH:"Colorectal Neoplasms") increases p(HGNC:VRK1) View Subject | View Object

Appears in Networks:

path(MESH:"Colorectal Neoplasms") decreases p(HGNC:ABCD3) View Subject | View Object

Appears in Networks:

path(MESH:"Colorectal Neoplasms") increases p(HGNC:GLRX2) View Subject | View Object

Appears in Networks:

path(MESH:"Colorectal Neoplasms") increases p(HGNC:MICB) View Subject | View Object

Appears in Networks:

path(MESH:"Colorectal Neoplasms") increases p(HGNC:NQO1) View Subject | View Object

Appears in Networks:

Evidence 3c91b98d45
JSON

In addition, Protandim downregulated the one gene targeted by a chemotherapeutic drug, an antimetabolite inhibitor for that gene’s product, thymidylate synthetase

a(PUBCHEM:135316034) decreases p(HGNC:TYMS) View Subject | View Object

Appears in Networks:

Evidence db79e24260
JSON

Bardoxolone methyl appeared to produce a biphasic induction, producing near maximal FI over a range of concentrations from less than 40 nM to 0.4 lM

a(PUBCHEM:400769) increases act(p(HGNC:NFE2L2)) View Subject | View Object

Appears in Networks:

Evidence 133672b9c9
JSON

After 52 weeks, the estimated glomerular filtration rate in the 75 mg/day treatment group had increased by 10.5 ± 1.8 ml/min/1.73 m2 (p < 0.001), representing an increase of about 32% when compared to entry values.

a(PUBCHEM:400769) increases bp(GO:"glomerular filtration") View Subject | View Object

Appears in Networks:

Evidence ef967db506
JSON

Patients with relapsing-remitting multiple sclerosis treated with BG-12 for 24 weeks showed significantly fewer new gadolinium-enhancing lesions, with significantly reduced probability of their evolution to T1-hypointense lesions than patients treated with placebo (Macmanus et al., 2011)

a(PUBCHEM:400769) negativeCorrelation path(MESH:"Multiple Sclerosis, Relapsing-Remitting") View Subject | View Object

Appears in Networks:

path(MESH:"Multiple Sclerosis, Relapsing-Remitting") negativeCorrelation a(PUBCHEM:400769) View Subject | View Object

Appears in Networks:

Evidence 59450b2708
JSON

The study suggests that Nrf2 activation represents a viable new therapeutic approach for renal disease, as similar results are not achievable with currently available therapies

act(p(HGNC:NFE2L2)) negativeCorrelation path(MESH:"Kidney Diseases") View Subject | View Object

Appears in Networks:

path(MESH:"Kidney Diseases") negativeCorrelation act(p(HGNC:NFE2L2)) View Subject | View Object

Appears in Networks:

Evidence 09133ff384
JSON

These studies suggest that Nrf2 activation may represent a promising new therapeutic approach for multiple sclerosis.

act(p(HGNC:NFE2L2)) negativeCorrelation path(MESH:"Multiple Sclerosis, Relapsing-Remitting") View Subject | View Object

Appears in Networks:

path(MESH:"Multiple Sclerosis, Relapsing-Remitting") negativeCorrelation act(p(HGNC:NFE2L2)) View Subject | View Object

Appears in Networks:

Evidence c78a19ee63
JSON

Sirtuin 1 (SIRT1) was shown to decrease acetylation of Nrf2, as well as Nrf2-dependent transcription.

p(HGNC:SIRT1) decreases p(HGNC:NFE2L2, pmod(Ac)) View Subject | View Object

Appears in Networks:

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.