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p(HGNC:ANP32A)

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
ANP32A
Namespace
hgnc
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns

Appears in Networks 3

Oxidative stress in health and disease: The therapeutic potential of Nrf2 activation v1.0.0

Protein phosphatase 2A dysfunction in Alzheimer’s disease v1.0.0

PP2A and Alzheimer Disease v1.0.0

In-Edges 7

a(PUBCHEM:135316034) decreases p(HGNC:ANP32A) View Subject | View Object

In Alzheimer disease, 66 genes were identified that are also modulated by Protandim at the gene expression level. Of these 66 genes, the first 43 of them (65%) were regulated by Protandim in the opposing direction to that taken by the Alzheimer disease process. The beneficial effect of Protandim is further supported by the fact that of the 10 gene products currently targeted by drug therapies, eight of them are modulated by Protandim in the same direction that is proposed to be beneficial and caused by the drug. PubMed:22020111

Appears in Networks:
Annotations
MeSH
Alzheimer Disease

path(MESH:"Alzheimer Disease") increases p(HGNC:ANP32A) View Subject | View Object

In Alzheimer disease, 66 genes were identified that are also modulated by Protandim at the gene expression level. Of these 66 genes, the first 43 of them (65%) were regulated by Protandim in the opposing direction to that taken by the Alzheimer disease process. The beneficial effect of Protandim is further supported by the fact that of the 10 gene products currently targeted by drug therapies, eight of them are modulated by Protandim in the same direction that is proposed to be beneficial and caused by the drug. PubMed:22020111

Appears in Networks:

act(complex(GO:"protein phosphatase type 2A complex")) negativeCorrelation p(HGNC:ANP32A) View Subject | View Object

Up-regulation of I1 PP2A and I2 PP2A, and mislocalization and cleavage of I2 PP2A, could underlie the inactivation of PP2A in AD neocortical neurons (Tanimukai et al.,2005). PubMed:24653673

Appears in Networks:
Annotations
MeSH
Neocortex
MeSH
Alzheimer Disease

complex(p(HGNC:ANP32A), p(HGNC:PPP2CA)) hasComponent p(HGNC:ANP32A) View Subject | View Object

Appears in Networks:

complex(p(HGNC:ANP32A), p(HGNC:PPP2CB)) hasComponent p(HGNC:ANP32A) View Subject | View Object

Appears in Networks:

path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:ANP32A) View Subject | View Object

Up-regulation of I1 PP2A and I2 PP2A, and mislocalization and cleavage of I2 PP2A, could underlie the inactivation of PP2A in AD neocortical neurons (Tanimukai et al.,2005). PubMed:24653673

Appears in Networks:
Annotations
MeSH
Neocortex
MeSH
Alzheimer Disease

path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:ANP32A) View Subject | View Object

Complementing these findings, immu- nohistochemical and western blot studies have shown re- duced expression of PPMT [77], and up-regulation of the PP2A inhibitors I 1 and I 2 in AD cases [79, 80]. PubMed:22299660

Appears in Networks:

Out-Edges 7

p(HGNC:ANP32A) decreases act(complex(GO:"protein phosphatase type 2A complex")) View Subject | View Object

Natural toxins such as okadaic acid, calyculin ,and fostriecin (Reviewed in Swingle et al., 2007), and endogenous nuclear inhibitors called I1 PP2A and I2 PP2A/SET (Li and Damuni, 1998), can directly bind to the catalytic subunit and inhibit the phosphatase activity of the entire family of PP2A enzymes. PubMed:24653673

Appears in Networks:

p(HGNC:ANP32A) negativeCorrelation act(complex(GO:"protein phosphatase type 2A complex")) View Subject | View Object

Up-regulation of I1 PP2A and I2 PP2A, and mislocalization and cleavage of I2 PP2A, could underlie the inactivation of PP2A in AD neocortical neurons (Tanimukai et al.,2005). PubMed:24653673

Appears in Networks:
Annotations
MeSH
Neocortex
MeSH
Alzheimer Disease

p(HGNC:ANP32A) increases complex(p(HGNC:ANP32A), p(HGNC:PPP2CA)) View Subject | View Object

Natural toxins such as okadaic acid, calyculin ,and fostriecin (Reviewed in Swingle et al., 2007), and endogenous nuclear inhibitors called I1 PP2A and I2 PP2A/SET (Li and Damuni, 1998), can directly bind to the catalytic subunit and inhibit the phosphatase activity of the entire family of PP2A enzymes. PubMed:24653673

Appears in Networks:

p(HGNC:ANP32A) increases complex(p(HGNC:ANP32A), p(HGNC:PPP2CB)) View Subject | View Object

Natural toxins such as okadaic acid, calyculin ,and fostriecin (Reviewed in Swingle et al., 2007), and endogenous nuclear inhibitors called I1 PP2A and I2 PP2A/SET (Li and Damuni, 1998), can directly bind to the catalytic subunit and inhibit the phosphatase activity of the entire family of PP2A enzymes. PubMed:24653673

Appears in Networks:

p(HGNC:ANP32A) positiveCorrelation path(MESH:"Alzheimer Disease") View Subject | View Object

Up-regulation of I1 PP2A and I2 PP2A, and mislocalization and cleavage of I2 PP2A, could underlie the inactivation of PP2A in AD neocortical neurons (Tanimukai et al.,2005). PubMed:24653673

Appears in Networks:
Annotations
MeSH
Neocortex
MeSH
Alzheimer Disease

p(HGNC:ANP32A) decreases act(p(FPLX:PPP2)) View Subject | View Object

Complementing these findings, immu- nohistochemical and western blot studies have shown re- duced expression of PPMT [77], and up-regulation of the PP2A inhibitors I 1 and I 2 in AD cases [79, 80]. PubMed:22299660

Appears in Networks:

p(HGNC:ANP32A) positiveCorrelation path(MESH:"Alzheimer Disease") View Subject | View Object

Complementing these findings, immu- nohistochemical and western blot studies have shown re- duced expression of PPMT [77], and up-regulation of the PP2A inhibitors I 1 and I 2 in AD cases [79, 80]. PubMed:22299660

Appears in Networks:

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.