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a(CHEBI:cocaine)

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Entity

Name
cocaine
Namespace
chebi
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/chebi-names.belns

Appears in Networks 2

M1 muscarinic acetylcholine receptor in Alzheimer’s disease v1.0.0

This file encodes the article M1 muscarinic acetylcholine receptor in Alzheimer’s disease by Jiang et al, 2014

Oxidative stress in health and disease: The therapeutic potential of Nrf2 activation v1.0.0

In-Edges 1

p(HGNC:CHRM5) increases act(a(CHEBI:cocaine)) View Subject | View Object

M5 mAChR is predominantly distributed in the pars compacta of the substantia nigra, a structure that provides dopaminergic innervation to the striatum, and in the ventral tegmental area, a structure providing dopaminergic innervation to the nucleus accumbens and other limbic areas[26, 57]. These areas are well known to play a critical role in the rewarding effects of several drugs of abuse. M5 mAChR-knockout mice are less sensitive to addictive drugs such as morphine and cocaine[58]. PubMed:24590577

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Out-Edges 1

a(CHEBI:cocaine) decreases act(p(HGNC:SLC7A11)) View Subject | View Object

This antiporter was recently found to be decreased by repeated cocaine exposure, and restoration of the activity prevented cocaine-primed drug seeking behavior in rats (Baker et al., 2003). PubMed:22020111

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.