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p(HGNC:UBA1)

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Entity

Name
UBA1
Namespace
hgnc
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns

Appears in Networks 6

The Ubiquitin Proteasome System in Neurodegenerative Diseases: Sometimes the Chicken, Sometimes the Egg v1.0.0

Perilous journey: a tour of the ubiquitin–proteasome system v1.0.0

Clearance of Amyloid Beta and Tau in Alzheimer’s Disease:from Mechanisms to Therapy v1.0.1

Oxidative stress in health and disease: The therapeutic potential of Nrf2 activation v1.0.0

The Ubiquitin–Proteasome System and the Autophagic–Lysosomal System in Alzheimer Disease v1.0.0

Autophagy and the ubiquitin-proteasome system: collaborators in neuroprotection v1.0.0

In-Edges 6

complex(a(MESH:Ubiquitin), p(HGNC:UBA1)) hasComponent p(HGNC:UBA1) View Subject | View Object

Appears in Networks:

composite(a(CHEBI:ATP), p(HGNC:UBA1)) hasComponent p(HGNC:UBA1) View Subject | View Object

Appears in Networks:

path(MESH:"Alzheimer Disease") negativeCorrelation act(p(HGNC:UBA1)) View Subject | View Object

Finally, there is also evidence for a reduced activity of E1 and E2 enzymes in cerebral cortex samples from AD patients compared to age-matched controls (Lopez Salon et al., 2000). PubMed:14556719

Appears in Networks:
Annotations
MeSH
Cerebral Cortex

complex(a(CHEBI:ATP), p(HGNC:UBA1)) hasComponent p(HGNC:UBA1) View Subject | View Object

Appears in Networks:

a(PUBCHEM:135316034) decreases p(HGNC:UBA1) View Subject | View Object

In colon carcinoma, IPA analysis revealed 28 genes associated with the disease that were also modulated by Protandim treatment. Of these, the first 25 listed (89%) were regulated by Protandim in the opposing direction to that taken by the colon carcinoma disease process. PubMed:22020111

Appears in Networks:
Annotations
MeSH
Colorectal Neoplasms

path(MESH:"Colorectal Neoplasms") increases p(HGNC:UBA1) View Subject | View Object

In colon carcinoma, IPA analysis revealed 28 genes associated with the disease that were also modulated by Protandim treatment. Of these, the first 25 listed (89%) were regulated by Protandim in the opposing direction to that taken by the colon carcinoma disease process. PubMed:22020111

Appears in Networks:

Out-Edges 4

act(p(HGNC:UBA1)) negativeCorrelation path(MESH:"Alzheimer Disease") View Subject | View Object

Finally, there is also evidence for a reduced activity of E1 and E2 enzymes in cerebral cortex samples from AD patients compared to age-matched controls (Lopez Salon et al., 2000). PubMed:14556719

Appears in Networks:
Annotations
MeSH
Cerebral Cortex

p(HGNC:UBA1) increases deg(a(MESH:Proteins)) View Subject | View Object

Under physiological conditions, UPS, located in the cytosol and the nucleus in eukaryotic cells, as a major intracellular short-lived protein degradation system (Schwartz and Ciechanover 2009), mediates the clearance of misfolded or other abnormally modified proteins with the help of ubiquitin-activating enzyme (E1), ubiquitin-conjugating enzyme (E2), ubiquitin ligase (E3), and the 26S proteasome for the sake of preventing the accumulation of toxic substances (Shang and Taylor 2011) PubMed:29626319

Appears in Networks:
Annotations
MeSH
Cell Nucleus
MeSH
Cytosol

p(HGNC:UBA1) increases bp(GO:autophagy) View Subject | View Object

This model is consistent with an older study showing that inactivation of the ubiquitin-activating enzyme E1 leads to a defect in autolysosomal degradation and to an absence of ubiquitin-positive proteins within lysosomes [68]. PubMed:18930136

Appears in Networks:

p(HGNC:UBA1) increases bp(GO:"protein ubiquitination") View Subject | View Object

This model is consistent with an older study showing that inactivation of the ubiquitin-activating enzyme E1 leads to a defect in autolysosomal degradation and to an absence of ubiquitin-positive proteins within lysosomes [68]. PubMed:18930136

Appears in Networks:

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.