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p(HGNC:HSPB8)

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Entity

Name
HSPB8
Namespace
hgnc
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns

Appears in Networks 4

A Quantitative Chaperone Interaction Network Reveals the Architecture of Cellular Protein Homeostasis Pathways v1.0.0

Oxidative stress in health and disease: The therapeutic potential of Nrf2 activation v1.0.0

Model systems of protein-misfolding diseases reveal chaperone modifiers of proteotoxicity v1.0.0

Molecular chaperones and proteostasis regulation during redox imbalance v1.0.0

In-Edges 4

complex(p(HGNC:BAG3), p(HGNC:HSPB8)) hasComponent p(HGNC:HSPB8) View Subject | View Object

Appears in Networks:

a(PUBCHEM:135316034) increases p(HGNC:HSPB8) View Subject | View Object

HSPB8, induced 19-fold, is a heat shock protein that forms a complex with BAG3 (also induced 1.43-fold). PubMed:22020111

Appears in Networks:

a(HBP:"amyloid-beta aggregates") association p(HGNC:HSPB8) View Subject | View Object

The importance of sHSPs in disease was originally noted from the observations that HSPB1 and CRYAB were overexpressed in AD brains (Shinohara et al., 1993; Renkawek et al., 1994a,b) and HSPB1, CRYAB, HSPB6 and HSPB8 were associated with AD plaques (Shao et al., 2012). PubMed:27491084

Appears in Networks:

p(HGNC:EIF2A) association p(HGNC:HSPB8) View Subject | View Object

Moreover, HSP22 stimu- lates autophagy-mediated degradation of protein aggregates in an eIF2α-dependent manner [30]. PubMed:24563850

Appears in Networks:

Out-Edges 4

p(HGNC:HSPB8) increases complex(p(HGNC:BAG3), p(HGNC:HSPB8)) View Subject | View Object

HSPB8, induced 19-fold, is a heat shock protein that forms a complex with BAG3 (also induced 1.43-fold). PubMed:22020111

Appears in Networks:

p(HGNC:HSPB8) association a(HBP:"amyloid-beta aggregates") View Subject | View Object

The importance of sHSPs in disease was originally noted from the observations that HSPB1 and CRYAB were overexpressed in AD brains (Shinohara et al., 1993; Renkawek et al., 1994a,b) and HSPB1, CRYAB, HSPB6 and HSPB8 were associated with AD plaques (Shao et al., 2012). PubMed:27491084

Appears in Networks:

p(HGNC:HSPB8) association p(HGNC:EIF2A) View Subject | View Object

Moreover, HSP22 stimu- lates autophagy-mediated degradation of protein aggregates in an eIF2α-dependent manner [30]. PubMed:24563850

Appears in Networks:

p(HGNC:HSPB8) increases bp(GO:"chaperone-mediated autophagy") View Subject | View Object

Moreover, HSP22 stimu- lates autophagy-mediated degradation of protein aggregates in an eIF2α-dependent manner [30]. PubMed:24563850

Appears in Networks:

About

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.