p(MGI:Dyrk1a) negativeCorrelation p(HBP:"4R tau")

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PubMed:28775333

Inhibition of Dyrk1A enhanced tau exon 10 inclusion, leading to an increase in 4R-tau/3R-tau ratio in differentiated-human neuronal progenitors and in the neonatal rat brains. Accompanied with overexpression of Dyrk1A, 3R-tau was increased and 4R-tau was decreased in the neonatal brains of Ts65Dn mice, a model of Down syndrome.

Related Edges 3

• p(MGI:Dyrk1a) positiveCorrelation p(HBP:"3R tau")
• p(HBP:"3R tau") positiveCorrelation p(MGI:Dyrk1a)
• p(HBP:"4R tau") negativeCorrelation p(MGI:Dyrk1a)

MeSH

Alzheimer Disease

MeSH

Down Syndrome

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