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PubMed: 28775333

Title
Dual-specificity tyrosine-phosphorylation regulated kinase 1A Gene Transcription is regulated by Myocyte Enhancer Factor 2D.
Journal
Scientific reports
Volume
7
Issue
None
Pages
7240
Date
2017-08-03
Authors
Chen L | Sun X | Wang L | Wang P

Evidence 591d0f5478
JSON

Treatment with Dyrk1A inhibitor, green tea flavonol epigallocatechin-gallate (EGCG), from gestation to adulthood suppressed 3R-tau expression and rescued anxiety and memory deficits in Ts65Dn mouse brains.

a(CHEBI:"(-)-epigallocatechin 3-gallate") decreases p(MGI:Dyrk1a) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease
MeSH
Down Syndrome

a(CHEBI:"(-)-epigallocatechin 3-gallate") negativeCorrelation p(HBP:"3R tau") View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease
MeSH
Down Syndrome

a(CHEBI:"(-)-epigallocatechin 3-gallate") decreases path(MESH:Anxiety) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease
MeSH
Down Syndrome

a(CHEBI:"(-)-epigallocatechin 3-gallate") positiveCorrelation bp(GO:memory) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease
MeSH
Down Syndrome

bp(GO:memory) positiveCorrelation a(CHEBI:"(-)-epigallocatechin 3-gallate") View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease
MeSH
Down Syndrome

bp(GO:memory) negativeCorrelation p(MGI:Dyrk1a) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease
MeSH
Down Syndrome

p(MGI:Dyrk1a) positiveCorrelation path(MESH:Anxiety) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease
MeSH
Down Syndrome

p(MGI:Dyrk1a) negativeCorrelation bp(GO:memory) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease
MeSH
Down Syndrome

p(HBP:"3R tau") negativeCorrelation a(CHEBI:"(-)-epigallocatechin 3-gallate") View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease
MeSH
Down Syndrome

path(MESH:Anxiety) positiveCorrelation p(MGI:Dyrk1a) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease
MeSH
Down Syndrome

Evidence 4f0a93a4eb
JSON

Inhibition of Dyrk1A enhanced tau exon 10 inclusion, leading to an increase in 4R-tau/3R-tau ratio in differentiated-human neuronal progenitors and in the neonatal rat brains. Accompanied with overexpression of Dyrk1A, 3R-tau was increased and 4R-tau was decreased in the neonatal brains of Ts65Dn mice, a model of Down syndrome.

p(MGI:Dyrk1a) positiveCorrelation p(HBP:"3R tau") View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease
MeSH
Down Syndrome

p(MGI:Dyrk1a) negativeCorrelation p(HBP:"4R tau") View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease
MeSH
Down Syndrome

p(HBP:"3R tau") positiveCorrelation p(MGI:Dyrk1a) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease
MeSH
Down Syndrome

p(HBP:"4R tau") negativeCorrelation p(MGI:Dyrk1a) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Alzheimer Disease
MeSH
Down Syndrome

Evidence 63a6084a87
JSON

Here we demonstrated that MEF2D could upregulate DYRK1A gene expression through specific activation of DYRK1A isoform 5 gene transcription. The coordinated expression of DYRK1A and MEF2D in mouse brain development indicated a possibility of the cross-interaction of these two genes during neurodevelopment. The DYRK1A kinase activity was also affected by MEF2D's transcriptional regulation of DYRK1A.

p(MGI:Mef2d) increases r(MGI:Dyrk1a) View Subject | View Object

Appears in Networks:

p(MGI:Mef2d) increases act(p(MGI:Dyrk1a), ma(kin)) View Subject | View Object

Appears in Networks:

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