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a(CHEBI:"(-)-epigallocatechin 3-gallate")

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
(-)-epigallocatechin 3-gallate
Namespace
chebi
Namespace Version
20180828
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/1b20f0637c395f8aa89c2e2e342d7b704062c242/external/chebi-names.belns

Appears in Networks 3

Alpha-synuclein oligomers: a new hope v1.0.0

Clearance of Amyloid Beta and Tau in Alzheimer’s Disease:from Mechanisms to Therapy v1.0.1

Tau Modifications v1.9.5

Tau Modifications Sections of NESTOR

In-Edges 2

bp(GO:memory) positiveCorrelation a(CHEBI:"(-)-epigallocatechin 3-gallate") View Subject | View Object

Treatment with Dyrk1A inhibitor, green tea flavonol epigallocatechin-gallate (EGCG), from gestation to adulthood suppressed 3R-tau expression and rescued anxiety and memory deficits in Ts65Dn mouse brains. PubMed:28775333

Appears in Networks:
Annotations
MeSH
Alzheimer Disease
MeSH
Down Syndrome

p(HBP:"3R tau") negativeCorrelation a(CHEBI:"(-)-epigallocatechin 3-gallate") View Subject | View Object

Treatment with Dyrk1A inhibitor, green tea flavonol epigallocatechin-gallate (EGCG), from gestation to adulthood suppressed 3R-tau expression and rescued anxiety and memory deficits in Ts65Dn mouse brains. PubMed:28775333

Appears in Networks:
Annotations
MeSH
Alzheimer Disease
MeSH
Down Syndrome

Out-Edges 10

a(CHEBI:"(-)-epigallocatechin 3-gallate") decreases a(HBP:HBP00016) View Subject | View Object

Epigallocatechin-3-gallate (EGCG), a small molecule that been shown to inhibit the aggregation of several amyloidogenic proteins such as a-syn, amyloid-beta and huntingtin [9, 37, 38, 105] binds to unfolded native amyloid-beta and a-syn and promotes the formation of nontoxic oligomers that do not convert into amyloid fibrils [37]. PubMed:28803412

Appears in Networks:
Annotations
Confidence
High
MeSH
Brain
MeSH
Cerebrospinal Fluid
MeSH
Serum

a(CHEBI:"(-)-epigallocatechin 3-gallate") decreases a(HBP:HBP00018) View Subject | View Object

Epigallocatechin-3-gallate (EGCG), a small molecule that been shown to inhibit the aggregation of several amyloidogenic proteins such as a-syn, amyloid-beta and huntingtin [9, 37, 38, 105] binds to unfolded native amyloid-beta and a-syn and promotes the formation of nontoxic oligomers that do not convert into amyloid fibrils [37]. PubMed:28803412

Appears in Networks:
Annotations
Confidence
High
MeSH
Brain
MeSH
Cerebrospinal Fluid
MeSH
Serum

a(CHEBI:"(-)-epigallocatechin 3-gallate") decreases a(HBP:HBP00017) View Subject | View Object

Epigallocatechin-3-gallate (EGCG), a small molecule that been shown to inhibit the aggregation of several amyloidogenic proteins such as a-syn, amyloid-beta and huntingtin [9, 37, 38, 105] binds to unfolded native amyloid-beta and a-syn and promotes the formation of nontoxic oligomers that do not convert into amyloid fibrils [37]. PubMed:28803412

Appears in Networks:
Annotations
Confidence
High
MeSH
Brain
MeSH
Cerebrospinal Fluid
MeSH
Serum

a(CHEBI:"(-)-epigallocatechin 3-gallate") decreases p(HGNC:MAPT, pmod(Ph)) View Subject | View Object

Epigallocatechin-3-gallate enhances the clearance of ADrelevant phosphorylated tau species via increasing mRNA expression of autophagy adaptor proteins NDP52 and p62 (Chesser et al. 2016) PubMed:29626319

Appears in Networks:

a(CHEBI:"(-)-epigallocatechin 3-gallate") increases p(HGNC:CALCOCO2) View Subject | View Object

Epigallocatechin-3-gallate enhances the clearance of ADrelevant phosphorylated tau species via increasing mRNA expression of autophagy adaptor proteins NDP52 and p62 (Chesser et al. 2016) PubMed:29626319

Appears in Networks:

a(CHEBI:"(-)-epigallocatechin 3-gallate") increases p(HGNC:SQSTM1) View Subject | View Object

Epigallocatechin-3-gallate enhances the clearance of ADrelevant phosphorylated tau species via increasing mRNA expression of autophagy adaptor proteins NDP52 and p62 (Chesser et al. 2016) PubMed:29626319

Appears in Networks:

a(CHEBI:"(-)-epigallocatechin 3-gallate") decreases p(MGI:Dyrk1a) View Subject | View Object

Treatment with Dyrk1A inhibitor, green tea flavonol epigallocatechin-gallate (EGCG), from gestation to adulthood suppressed 3R-tau expression and rescued anxiety and memory deficits in Ts65Dn mouse brains. PubMed:28775333

Appears in Networks:
Annotations
MeSH
Alzheimer Disease
MeSH
Down Syndrome

a(CHEBI:"(-)-epigallocatechin 3-gallate") negativeCorrelation p(HBP:"3R tau") View Subject | View Object

Treatment with Dyrk1A inhibitor, green tea flavonol epigallocatechin-gallate (EGCG), from gestation to adulthood suppressed 3R-tau expression and rescued anxiety and memory deficits in Ts65Dn mouse brains. PubMed:28775333

Appears in Networks:
Annotations
MeSH
Alzheimer Disease
MeSH
Down Syndrome

a(CHEBI:"(-)-epigallocatechin 3-gallate") decreases path(MESH:Anxiety) View Subject | View Object

Treatment with Dyrk1A inhibitor, green tea flavonol epigallocatechin-gallate (EGCG), from gestation to adulthood suppressed 3R-tau expression and rescued anxiety and memory deficits in Ts65Dn mouse brains. PubMed:28775333

Appears in Networks:
Annotations
MeSH
Alzheimer Disease
MeSH
Down Syndrome

a(CHEBI:"(-)-epigallocatechin 3-gallate") positiveCorrelation bp(GO:memory) View Subject | View Object

Treatment with Dyrk1A inhibitor, green tea flavonol epigallocatechin-gallate (EGCG), from gestation to adulthood suppressed 3R-tau expression and rescued anxiety and memory deficits in Ts65Dn mouse brains. PubMed:28775333

Appears in Networks:
Annotations
MeSH
Alzheimer Disease
MeSH
Down Syndrome

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.