g(DBSNP:rs63750424) negativeCorrelation complex(p(HGNC:DCTN1), p(HGNC:MAPT))

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PubMed:8391280

Mutations of a conserved arginine residue in the Nterminus of tau, found in patients with FTDP-17, affect its binding to dynactin, which is abnormally distributed in the retinal ganglion cell axons of transgenic mice expressing human tau with a mutation in the microtubule-binding domain.

Related Edges 3

• complex(p(HGNC:DCTN1), p(HGNC:MAPT)) negativeCorrelation g(DBSNP:rs63750424)
• g(DBSNP:rs63750424) positiveCorrelation path(MESH:"Frontotemporal Dementia")
• path(MESH:"Frontotemporal Dementia") positiveCorrelation g(DBSNP:rs63750424)

Uberon

ganglionic layer of retina

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