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PubMed: 8391280

Title
Ubiquitin is conjugated with amino-terminally processed tau in paired helical filaments.
Journal
Neuron
Volume
10
Issue
None
Pages
1151-60
Date
1993-06-01
Authors
Takio K | Ihara Y | Morishima-Kawashima M | Titani K | Hasegawa M | Suzuki M

Evidence 3f8e5e9dac
JSON

Tau and dynactin show extensive colocalization, and the attachment of the dynactin complex to microtubules is enhanced by tau.

p(HGNC:MAPT) increases act(p(INTERPRO:"Dynein associated protein")) View Subject | View Object

Appears in Networks:

complex(a(MESH:Microtubules), p(INTERPRO:"Dynein associated protein")) positiveCorrelation act(p(INTERPRO:"Dynein associated protein")) View Subject | View Object

Appears in Networks:

act(p(INTERPRO:"Dynein associated protein")) positiveCorrelation complex(a(MESH:Microtubules), p(INTERPRO:"Dynein associated protein")) View Subject | View Object

Appears in Networks:

Evidence e5a976806c
JSON

Mutations of a conserved arginine residue in the Nterminus of tau, found in patients with FTDP-17, affect its binding to dynactin, which is abnormally distributed in the retinal ganglion cell axons of transgenic mice expressing human tau with a mutation in the microtubule-binding domain.

complex(p(HGNC:DCTN1), p(HGNC:MAPT)) negativeCorrelation g(DBSNP:rs63750424) View Subject | View Object

Appears in Networks:
Annotations
Uberon
ganglionic layer of retina

g(DBSNP:rs63750424) positiveCorrelation path(MESH:"Frontotemporal Dementia") View Subject | View Object

Appears in Networks:
Annotations
Uberon
ganglionic layer of retina

g(DBSNP:rs63750424) negativeCorrelation complex(p(HGNC:DCTN1), p(HGNC:MAPT)) View Subject | View Object

Appears in Networks:
Annotations
Uberon
ganglionic layer of retina

path(MESH:"Frontotemporal Dementia") positiveCorrelation g(DBSNP:rs63750424) View Subject | View Object

Appears in Networks:
Annotations
Uberon
ganglionic layer of retina

Evidence a09c29b77d
JSON

We show here for the first time that the N-terminal projection domain of tau binds to the C-terminus of the p150 subunit of the dynactin complex. The sequences of tau encoded by exons 1 and 4, which lie at the tip of the N-terminal projection domain, interact with the C-terminal region of p150.

p(HGNC:DCTN1) association p(INTERPRO:"MAP2/Tau projection") View Subject | View Object

Appears in Networks:

p(INTERPRO:"MAP2/Tau projection") association p(HGNC:DCTN1) View Subject | View Object

Appears in Networks:

Evidence ffa3d24855
JSON

The ubiquitin-targeted protein was identified as tau in paired helical filaments, and the conjugation sites were localized to the microtubule-binding region.

p(FPLX:Ubiquitin) association p(HBP:"microtubule-binding region") View Subject | View Object

Appears in Networks:

p(FPLX:Ubiquitin) directlyIncreases p(HGNC:MAPT, pmod(Ub)) View Subject | View Object

Appears in Networks:

p(HBP:"microtubule-binding region") association p(FPLX:Ubiquitin) View Subject | View Object

Appears in Networks:

p(HGNC:MAPT, pmod(Ub)) increases deg(p(HGNC:MAPT)) View Subject | View Object

Appears in Networks:

Evidence 9a8373afda
JSON

Ubiquitination occurs at lysines (K254, K257 K311) in repeat domain; participates in triage process

a(HBP:"paired helical filaments") positiveCorrelation p(HGNC:MAPT, pmod(Ub, Lys, 254)) View Subject | View Object

Appears in Networks:

a(HBP:"paired helical filaments") positiveCorrelation p(HGNC:MAPT, pmod(Ub, Lys, 257)) View Subject | View Object

Appears in Networks:

a(HBP:"paired helical filaments") positiveCorrelation p(HGNC:MAPT, pmod(Ub, Lys, 311)) View Subject | View Object

Appears in Networks:

p(HGNC:MAPT, pmod(Ub, Lys, 257)) positiveCorrelation a(HBP:"paired helical filaments") View Subject | View Object

Appears in Networks:

p(HGNC:MAPT, pmod(Ub, Lys, 311)) positiveCorrelation a(HBP:"paired helical filaments") View Subject | View Object

Appears in Networks:

p(HGNC:MAPT, pmod(Ub, Lys, 254)) positiveCorrelation a(HBP:"paired helical filaments") View Subject | View Object

Appears in Networks:

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.