composite(a(CHEBI:"amyloid-beta"), p(HGNC:CHRNA7)) increases act(p(HGNC:MAPK1))

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PubMed:19293145

Abeta initiates intracellular signaling cascades via nAChRs (Fig. 3), including the MAPK kinase signaling pathway, resulting in cell death. In hippocampal slices, Abeta activates ERK-2 isoforms of the ERK MAPK. This is blocked by alpha7 antagonists, suggesting that Abeta evokes the cascade through alpha7 nAChRs (Dineley et al., 2001).

Related Edges 1

• act(p(HGNC:MAPK1)) increases bp(GO:"apoptotic process")

MeSH

Hippocampus

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