complex(p(HGNC:BACE1), p(HGNC:GGA1)) decreases rxn(reactants(p(HGNC:APP)), products(a(CHEBI:"amyloid-beta")))

PubMed:21214928

On the other hand, Golgi-localized gamma-ear-containing ARF-binding (GGA) proteins have been found to interact with BACE1 and regulate its trafficking between the late Golgi and early endosomes; and depletion of GGA proteins increases the accumulation of BACE1 in acidic early endosomes for enhanced BACE1 stability and cleavage of APP [76-78]

MeSH

Endosomes

Confidence

High

MeSH

Neurons

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.