rxn(reactants(p(HGNC:APP)), products(a(CHEBI:"amyloid-beta")))
Abeta is generated from b-amyloid precursor protein (APP) through sequential cleavages first by beta-secretase and then by gamma-secretase complex PubMed:21214928
Cleavage of APP by caspases may also contribute to AD pathologies PubMed:21214928
Abeta is generated from b-amyloid precursor protein (APP) through sequential cleavages first by beta-secretase and then by gamma-secretase complex PubMed:21214928
On the other hand, Golgi-localized gamma-ear-containing ARF-binding (GGA) proteins have been found to interact with BACE1 and regulate its trafficking between the late Golgi and early endosomes; and depletion of GGA proteins increases the accumulation of BACE1 in acidic early endosomes for enhanced BACE1 stability and cleavage of APP [76-78] PubMed:21214928
Abeta is generated from b-amyloid precursor protein (APP) through sequential cleavages first by beta-secretase and then by gamma-secretase complex PubMed:21214928
The first step in Abeta generation is cleavage of APP by the beta-secretase PubMed:21214928
These results provide convincing evidence that BACE1 is the beta-secretase involved in APP metabolism [63-67]; and BACE1 activity is thought to be the rate-limiting factor in Abeta generation from APP PubMed:21214928
Some studies found that BACE1 can interact with reticulon/Nogo proteins, whose increased expression can block BACE1 in the ER with a neutral pH environment and thus inhibit BACE1 activity in Abeta generation [73-75] PubMed:21214928
As DS also results in Abeta accumulation, the genes location suggests a link between BACE2 and APP processing PubMed:21214928
Indeed, BACE2 cleaves beta-secretase substrates such as wild-type and Swedish mutant APP, similar to BACE1, in enzymatic In vitro assays [89] PubMed:21214928
The processing of APP to generate Abeta is executed by beta- and gamma-secretase and is highly regulated PubMed:22122372
The processing of APP to generate Abeta is executed by beta- and gamma-secretase and is highly regulated PubMed:22122372
As DS also results in Abeta accumulation, the genes location suggests a link between BACE2 and APP processing PubMed:21214928
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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.