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a(MESH:Caspases)

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Entity

Name
Caspases
Namespace
mesh
Namespace Version
20180828
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/1b20f0637c395f8aa89c2e2e342d7b704062c242/external/mesh-names.belns

Appears in Networks 3

APP processing in Alzheimer's disease v1.0.1

APP processing in Alzheimer's disease

Proteolytic processing of Alzeimer's beta-amyloid precursor protein v1.0.1

Multivalent cross-linking of actin filaments and microtubules through the microtubule-associated protein Tau v1.0.0

In-Edges 0

Out-Edges 7

a(MESH:Caspases) increases rxn(reactants(p(HGNC:APP)), products(a(CHEBI:"amyloid-beta"))) View Subject | View Object

Cleavage of APP by caspases may also contribute to AD pathologies PubMed:21214928

Appears in Networks:
Annotations
Confidence
Medium

a(MESH:Caspases) increases path(MESH:"Alzheimer Disease") View Subject | View Object

Cleavage of APP by caspases may also contribute to AD pathologies PubMed:21214928

Appears in Networks:
Annotations
Confidence
Medium

a(MESH:Caspases) increases rxn(reactants(p(HBP:HBP00071)), products(a(HBP:HBP00069), a(HBP:HBP00070))) View Subject | View Object

It is also possible that APP betaCTF’s cytotoxic effect is actually mediated by the end products of gamma- and/or caspase-cleavage including APP intracellular domain (AICD), C31 and Jcasp which are cytotoxic (see below) PubMed:21214928

Appears in Networks:
Annotations
MeSH
Endosomes
Confidence
Low
MeSH
Neurons

a(MESH:Caspases) increases rxn(reactants(p(HGNC:APP)), products(a(HBP:HBP00069))) View Subject | View Object

In addition to secretases, caspases (predominantly caspase- 3) can directly cleave APP at position Asp664 (based on the APP695 sequence) within the cytoplasmic tail during apoptosis to release a fragment containing the last 31 amino acids of APP (called C31) PubMed:21214928

Appears in Networks:
Annotations
MeSH
Endosomes
Confidence
High
MeSH
Neurons

a(MESH:Caspases) increases rxn(reactants(p(HGNC:APP)), products(a(HBP:HBP00070))) View Subject | View Object

Additional gamma-cleavage further generates the fragment (called Jcasp) containing the region between gamma- and caspase-cleavage sites PubMed:21214928

Appears in Networks:
Annotations
MeSH
Endosomes
Confidence
High
MeSH
Neurons

a(MESH:Caspases) increases rxn(reactants(p(HGNC:APP)), products(a(HBP:HBP00069), a(HBP:HBP00070))) View Subject | View Object

In addition to cleavages involving secretases, APP can be cleaved by caspases independently at its C terminus (Asp664 of APP695), releasing a short tail containing the last 31 amino acids (C31) of APP and a fragment (Jcasp) from between the gamma- and caspase-cleavage sites (Lu et al. 2000) PubMed:22122372

Appears in Networks:
Annotations
Confidence
High
MeSH
Neurons

a(MESH:Caspases) increases p(HGNC:MAPT, var("?")) View Subject | View Object

Truncation of Tau by caspases and endopeptidases has been suggested to constitute an important pathogenic step in AD PubMed:29215007

Appears in Networks:
Annotations
Confidence
High

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.