bp(GO:neurogenesis) negativeCorrelation act(p(FPLX:ERK))

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PubMed:24653673

Apart from affecting tau phosphorylation, abnormal activation of GSK3β, cdk5, and ERK has been linked to cytoskeletal abnormalities (microtubules, neurofilaments), alterations in amyloid precursor protein (APP) phosphorylation and processing, impairment of neurogenesis, alterations in synaptic plasticity and induction of apoptotic processes (Reviewed in Crews and Masliah, 2010; Medina and Avila, 2013, 2014).

Related Edges 41

• a(GO:"microtubule cytoskeleton") negativeCorrelation act(p(HGNC:GSK3B))
• a(GO:"microtubule cytoskeleton") negativeCorrelation act(p(HGNC:CDK5))
• a(GO:"microtubule cytoskeleton") negativeCorrelation act(p(FPLX:ERK))
• a(GO:"neurofilament cytoskeleton") negativeCorrelation act(p(HGNC:GSK3B))
• a(GO:"neurofilament cytoskeleton") negativeCorrelation act(p(HGNC:CDK5))
• a(GO:"neurofilament cytoskeleton") negativeCorrelation act(p(FPLX:ERK))
• bp(GO:"apoptotic process") positiveCorrelation act(p(HGNC:GSK3B))
• bp(GO:"apoptotic process") positiveCorrelation act(p(HGNC:CDK5))
• bp(GO:"apoptotic process") positiveCorrelation act(p(FPLX:ERK))
• bp(GO:"negative regulation of synaptic plasticity") positiveCorrelation act(p(HGNC:GSK3B))
• bp(GO:"negative regulation of synaptic plasticity") positiveCorrelation act(p(HGNC:CDK5))
• bp(GO:"negative regulation of synaptic plasticity") positiveCorrelation act(p(FPLX:ERK))
• bp(GO:neurogenesis) negativeCorrelation act(p(HGNC:GSK3B))
• bp(GO:neurogenesis) negativeCorrelation act(p(HGNC:CDK5))
• bp(HBP:"APP processing") negativeCorrelation act(p(HGNC:GSK3B))
• bp(HBP:"APP processing") negativeCorrelation act(p(HGNC:CDK5))
• bp(HBP:"APP processing") negativeCorrelation act(p(FPLX:ERK))
• act(p(HGNC:CDK5)) negativeCorrelation a(GO:"microtubule cytoskeleton")
• act(p(HGNC:CDK5)) negativeCorrelation a(GO:"neurofilament cytoskeleton")
• act(p(HGNC:CDK5)) negativeCorrelation p(HGNC:APP, pmod(Ph))
• act(p(HGNC:CDK5)) negativeCorrelation bp(HBP:"APP processing")
• act(p(HGNC:CDK5)) negativeCorrelation bp(GO:neurogenesis)
• act(p(HGNC:CDK5)) positiveCorrelation bp(GO:"negative regulation of synaptic plasticity")
• act(p(HGNC:CDK5)) positiveCorrelation bp(GO:"apoptotic process")
• act(p(HGNC:GSK3B)) negativeCorrelation a(GO:"microtubule cytoskeleton")
• act(p(HGNC:GSK3B)) negativeCorrelation a(GO:"neurofilament cytoskeleton")
• act(p(HGNC:GSK3B)) negativeCorrelation p(HGNC:APP, pmod(Ph))
• act(p(HGNC:GSK3B)) negativeCorrelation bp(HBP:"APP processing")
• act(p(HGNC:GSK3B)) negativeCorrelation bp(GO:neurogenesis)
• act(p(HGNC:GSK3B)) positiveCorrelation bp(GO:"negative regulation of synaptic plasticity")
• act(p(HGNC:GSK3B)) positiveCorrelation bp(GO:"apoptotic process")
• act(p(FPLX:ERK)) negativeCorrelation a(GO:"microtubule cytoskeleton")
• act(p(FPLX:ERK)) negativeCorrelation a(GO:"neurofilament cytoskeleton")
• act(p(FPLX:ERK)) negativeCorrelation p(HGNC:APP, pmod(Ph))
• act(p(FPLX:ERK)) negativeCorrelation bp(HBP:"APP processing")
• act(p(FPLX:ERK)) negativeCorrelation bp(GO:neurogenesis)
• act(p(FPLX:ERK)) positiveCorrelation bp(GO:"negative regulation of synaptic plasticity")
• act(p(FPLX:ERK)) positiveCorrelation bp(GO:"apoptotic process")
• p(HGNC:APP, pmod(Ph)) negativeCorrelation act(p(HGNC:GSK3B))
• p(HGNC:APP, pmod(Ph)) negativeCorrelation act(p(HGNC:CDK5))
• p(HGNC:APP, pmod(Ph)) negativeCorrelation act(p(FPLX:ERK))

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

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