a(GO:"neurofibrillary tangle") increases act(p(MGI:Stat1))

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PubMed:30126037

Consistent with NFTs from human AD, mouse NFTs also caused significant activation scores for IFNG, TNF, IL-1B, as well as enrichment in other senescence associated JAK, STAT, CDKN2A and BCL2 predicted upstream regulators (Figure 1c) indicating translational relevance for using tauNFT mice to explore our hypothesis

Related Edges 6

• a(GO:"neurofibrillary tangle") increases act(p(MGI:Cdkn2a))
• a(GO:"neurofibrillary tangle") increases act(p(MGI:Ifng))
• a(GO:"neurofibrillary tangle") increases act(p(MGI:Tnf))
• a(GO:"neurofibrillary tangle") increases act(p(MGI:Il1b))
• a(GO:"neurofibrillary tangle") increases act(p(MGI:Jak1))
• a(GO:"neurofibrillary tangle") increases act(p(MGI:Bcl2))

Confidence

Medium

MeSH

Neurons

MeSH

Alzheimer Disease

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

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