p(HGNC:PSEN1) increases bp(GO:"vacuolar acidification")

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PubMed:24027553

Mutations in PS1 were shown to impair the acidification of lysosomes, which is necessary for activating the proteolytic enzymes in this compartment. Improper acidification and impaired proteolysis of substrates would compromise the autophagy system and result in the accumulation of AVs as described above.

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• bp(GO:"vacuolar acidification") increases bp(GO:proteolysis)

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