a(CHEBI:nicotine) increases act(a(HBP:"alpha-4 beta-2 nAChR"))

PubMed:21482353

The upregulation of alpha4beta2* nAChRs by chronic nicotine treatment has been replicated many times in numerous systems—transfected cell lines, neurons in culture, brain slices, and smokers’ brains (Albuquerque et al., 2009; Fu et al., 2009; Lester et al., 2009; Srinivasan et al., 2011

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