p(HGNC:GSK3B) directlyIncreases p(HGNC:MAPT, frag("1_244"))

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PubMed:11812770

GSK3Beta may directly bind to tau within a GSK3Beta-tau complex.To identify the GSK3Beta-binding region within tau, we constructed three tau deletion mutants: R-tau-(1–244) containing the N-terminal projection domain, R-tau-(245–369) containing the microtubule-binding region, and R-tau-(245–441) containing both the microtubule-binding region and the C-terminal tail. We evaluated the binding of these mutants and wild-type R-tau with GST-GSK3Beta by the GST pull-down assay. GSK3Beta bound to wild type (Fig. 5B) and R-tau-(1–244) (Fig. 5C) but not R-tau-(245–369) (Fig. 5D) and R-tau-(245–441) (Fig.5E). These data demonstrate that GSK3Beta binds to the Nterminal projection domain of tau.

Related Edges 4

• p(HGNC:MAPT) positiveCorrelation complex(p(HGNC:GSK3B), p(HGNC:MAPT))
• complex(p(HGNC:GSK3B), p(HGNC:MAPT)) positiveCorrelation p(HGNC:GSK3B)
• complex(p(HGNC:GSK3B), p(HGNC:MAPT)) positiveCorrelation p(HGNC:MAPT)
• p(HGNC:GSK3B) positiveCorrelation complex(p(HGNC:GSK3B), p(HGNC:MAPT))

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