p(MGI:P2rx4) increases act(complex(GO:"NLRP1 inflammasome complex"))

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PubMed:24561250

Given that P2X4 and P2X7 are the major purinergic P2X receptor subtypes, a study of spinal cord injury in P2X4 knock-out mice showed a significant reduction in inflammasome activation and proinflammatory cytokine production as compared to wild type (de Rivero Vaccari et al., 2012), supporting the involvement of purinergic receptor P2X4 in the activation of the NLRP1 inflammasome

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• p(MGI:P2rx7) increases act(complex(GO:"NLRP1 inflammasome complex"))

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High

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