act(complex(GO:"NLRP3 inflammasome complex")) increases p(HGNC:IL1B)

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PubMed:28019679

Activation of NLRP3 leads to the generation of interleukin-1b (IL-1b) and interleukin 18 (IL-18), which are being cleaved by caspase-1 from their inactive precursors and subsequently

Related Edges 3

• act(complex(GO:"NLRP3 inflammasome complex")) increases p(HGNC:IL18)
• p(HGNC:CASP1) increases act(p(HGNC:IL18))
• p(HGNC:CASP1) increases act(p(HGNC:IL1B))

Confidence

Medium

NeuroMMSigDB

Caspase subgraph

NeuroMMSigDB

Interleukin signaling subgraph

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

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