p(HGNC:MTMR14) decreases act(p(FPLX:PI3K))

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PubMed:30116051

An unusual approach to augmenting autophagosome formation is represented by the brain- penetrant autophagy enhancer 99 (AUTEN-99), which blocks myotubularin-related protein 14 (MTMR14, also known as Jumpy), a phosphatase that inhibits the phos- phoinositide 3-kinase (PI3K)-mediated generation of the autophagosome membrane (FIG. 3) . AUTEN-99 aug- mented autophagic flux in isolated neurons, increased markers of autophagy in mouse brain and slowed neuro- degeneration in D. melanogaster models of PD and HD 181 .

Related Edges 4

• a(PUBCHEM:16240819) decreases act(p(HGNC:MTMR14))
• a(PUBCHEM:16240819) increases bp(GO:macroautophagy)
• a(PUBCHEM:16240819) decreases bp(HP:Neurodegeneration)
• act(p(FPLX:PI3K)) increases a(GO:"autophagosome membrane")

MeSH

Machado-Joseph Disease

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