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Machado-Joseph Disease

Name
Machado-Joseph Disease
Namespace Keyword
MeSHDisease
Namespace
MeSH
Namespace Version
20170511
Namespace URL
https://arty.scai.fraunhofer.de/artifactory/bel/annotation/mesh-diseases/mesh-diseases-20170511.belanno

Sample Annotated Edges 5

a(CHEBI:cilostazol) decreases p(HGNC:MAPT, pmod(HBP:HBP00007)) View Subject | View Object

Cilostazol improved cognition and reduced levels of Aβ42 and hyperphosphorylated tau following intra- cerebroventricular injection of Aβ25–35 into mice 162,163 . PubMed:30116051

Appears in Networks:
Annotations
MeSH
Machado-Joseph Disease

bp(GO:aging) decreases a(CHEBI:"NAD(+)") View Subject | View Object

Activity of the deacetylase SIRT1 declines with age, partially owing to limited availability of its co fac- tor, nicotinamide 24,56,156 . PubMed:30116051

Appears in Networks:
Annotations
MeSH
Dopaminergic Neurons
MeSH
Machado-Joseph Disease

complex(p(HGNC:BCL2), p(HGNC:BECN1)) decreases bp(GO:macroautophagy) View Subject | View Object

Disruption of this Bcl-2–beclin 1 complex is an alternative approach for promoting autophagy, as achieved in mouse fibroblasts by the BH3 mimetic ABT-737 (REF.177) . PubMed:30116051

Appears in Networks:
Annotations
MeSH
Machado-Joseph Disease

a(PUBCHEM:16240819) decreases bp(HP:Neurodegeneration) View Subject | View Object

An unusual approach to augmenting autophagosome formation is represented by the brain- penetrant autophagy enhancer 99 (AUTEN-99), which blocks myotubularin-related protein 14 (MTMR14, also known as Jumpy), a phosphatase that inhibits the phos- phoinositide 3-kinase (PI3K)-mediated generation of the autophagosome membrane (FIG. 3) . AUTEN-99 aug- mented autophagic flux in isolated neurons, increased markers of autophagy in mouse brain and slowed neuro- degeneration in D. melanogaster models of PD and HD 181 . PubMed:30116051

Appears in Networks:
Annotations
MeSH
Machado-Joseph Disease

path(MESH:"Alzheimer Disease") increases act(p(HGNC:ABL1)) View Subject | View Object

ABL1 is overactivated in AD and tauopathies such as FTD 152 . PubMed:30116051

Appears in Networks:
Annotations
MeSH
Dopaminergic Neurons
MeSH
Machado-Joseph Disease

Showing 5 of 58 edges

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.