bp(MESH:Aging) decreases p(FPLX:HSPA)

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PubMed:25784053

Additionally, an investigation of chaperone and cochaperone gene expression in young (36±4 years of age) and aged (73 ±4 years of age) human brain tissue revealed that of 332 genes examined, 101 are significantly repressed with age, including HSP70, HSP40, HSP90, and TRiC genes (113). Furthermore, 62 chaperone genes, including several small HSPs, were found to be significantly induced, likely as a result of the cellular response to accumulating protein damage with age (113).

Related Edges 3

• bp(MESH:Aging) decreases p(FPLX:HSP90)
• bp(MESH:Aging) decreases p(HGNCGENEFAMILY:"DNAJ (HSP40) heat shock proteins")
• bp(MESH:Aging) increases p(FPLX:HSPB)

Cell Ontology (CL)

motor neuron

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