path(MESH:D000544) decreases act(p(HGNC:ACHE))

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PubMed:18986241

Butyrylcholinesterase (BChE) is a serine hydrolase similar to AChE that is widely distributed throughout the CNS and also catalyzes the hydrolysis of ACh. BChE is localized to neurons and glia, and is associated with NFTs and senile plaques (SPs) in AD brain [32]. Interestingly, population-based genetic studies of AD have identified a point mutation that changes Ala539 to threonine in the K variant of BChE, which effectively reduces serum BChE concentrations, and may be associated with cognitive decline [33]. BChE activity also increases in AD brain whereas AChE activity remains unchanged or declines [34,35].

Related Edges 10

• a(MESH:D016874) association p(HGNC:BCHE)
• act(p(HGNC:BCHE), ma(cat)) directlyIncreases deg(a(CHEBI:acetylcholine))
• p(HGNC:BCHE) association a(MESH:D016874)
• p(HGNC:BCHE) association path(MESH:D058225)
• p(HGNC:BCHE) association path(MESH:D003071)
• p(HGNC:BCHE, var("p.Ala539Thr")) decreases p(HGNC:BCHE)
• path(MESH:D000544) causesNoChange act(p(HGNC:ACHE))
• path(MESH:D000544) increases act(p(HGNC:BCHE))
• path(MESH:D003071) association p(HGNC:BCHE)
• path(MESH:D058225) association p(HGNC:BCHE)

Disease Ontology (DO)

Alzheimer's disease

MeSH

Neuroglia

MeSH

Neurons

MeSH

Cognitive Dysfunction

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

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