a(CHEBI:heme) increases act(p(HGNC:TLR4))

PubMed:29610666

Purified heme was found to be an activator of TLR4 8,11,27 in some studies and of the inflammasome 9 in others, and these activities were considered to be the molecular mechanism behind the coexistence of inflammation and hemolysis.

Cell Ontology (CL)

macrophage

MeSH

Mitochondria

Text Location

Discussion

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