p(HBP:"delta 144-273 tau") decreases bp(GO:"anterograde axonal protein transport")

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PubMed:21734277

Consistent with our model, 􏰁144 –273 tau monomers significantly inhibited antero- grade FAT (Fig. 6 B, C), while retrograde FAT remained unaf- fected (Fig. 6 B, D).Together, these data indicate that disease- associated modifications and mutations in tau that increase exposure of PAD promote activation of the PP1–GSK3 pathway and inhibition of anterograde FAT.

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• p(HBP:"delta 144-273 tau") causesNoChange bp(GO:"retrograde axonal protein transport")

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