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p(HBP:"delta 144-273 tau")

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Entity

Name
delta 144-273 tau
Namespace
HBP
Namespace Version
None
Pattern
.*

Appears in Networks 1

Pathogenic forms of tau inhibit kinesin-dependent axonal transport through a mechanism involving activation of axonal phosphotransferases. v1.0.0

In-Edges 0

Out-Edges 2

p(HBP:"delta 144-273 tau") decreases bp(GO:"anterograde axonal protein transport") View Subject | View Object

Consistent with our model, 􏰁144 –273 tau monomers significantly inhibited antero- grade FAT (Fig. 6 B, C), while retrograde FAT remained unaf- fected (Fig. 6 B, D).Together, these data indicate that disease- associated modifications and mutations in tau that increase exposure of PAD promote activation of the PP1–GSK3 pathway and inhibition of anterograde FAT. PubMed:21734277

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p(HBP:"delta 144-273 tau") causesNoChange bp(GO:"retrograde axonal protein transport") View Subject | View Object

Consistent with our model, 􏰁144 –273 tau monomers significantly inhibited antero- grade FAT (Fig. 6 B, C), while retrograde FAT remained unaf- fected (Fig. 6 B, D).Together, these data indicate that disease- associated modifications and mutations in tau that increase exposure of PAD promote activation of the PP1–GSK3 pathway and inhibition of anterograde FAT. PubMed:21734277

Appears in Networks:

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.