p(HGNC:PSEN2, var("?")) increases p(HGNC:APP, frag("672_713"))

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PubMed:22122372

Transgenic mice over-expressing PSs with FAD mutations show significantly increased Abeta42 levels, suggesting that PS mutations probably induce AD by producing more of the hydrophobic Abeta42 form (Duff et al. 1996; Qian et al. 1998)

Related Edges 1

• p(HGNC:PSEN1, var("?")) increases p(HGNC:APP, frag("672_713"))

Confidence

Medium

MeSH

Neurons

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