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  3. p(HGNC:PSEN2, var("?"))

p(HGNC:PSEN2, var("?"))

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
PSEN2
Namespace
hgnc
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns

Appears in Networks 2

Proteolytic processing of Alzeimer's beta-amyloid precursor protein v1.0.1

The Ubiquitin Proteasome System in Neurodegenerative Diseases: Sometimes the Chicken, Sometimes the Egg v1.0.0

In-Edges 2

p(HGNC:PSEN2) hasVariant p(HGNC:PSEN2, var("?")) View Subject | View Object

Appears in Networks:

act(complex(GO:"gamma-secretase complex")) association p(HGNC:PSEN2, var("?")) View Subject | View Object

Finally, some patients express mutant presenilin proteins 1 and 2 (PS1 and PS2) that can change the processing of APP by altering gamma secretase activity, thereby promoting the generation of amyloidogenic Abeta (Hardy and Selkoe, 2002). PubMed:14556719

Appears in Networks:

Out-Edges 3

p(HGNC:PSEN2, var("?")) increases p(HGNC:APP, frag("672_713")) View Subject | View Object

Transgenic mice over-expressing PSs with FAD mutations show significantly increased Abeta42 levels, suggesting that PS mutations probably induce AD by producing more of the hydrophobic Abeta42 form (Duff et al. 1996; Qian et al. 1998) PubMed:22122372

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Neurons

p(HGNC:PSEN2, var("?")) association act(complex(GO:"gamma-secretase complex")) View Subject | View Object

Finally, some patients express mutant presenilin proteins 1 and 2 (PS1 and PS2) that can change the processing of APP by altering gamma secretase activity, thereby promoting the generation of amyloidogenic Abeta (Hardy and Selkoe, 2002). PubMed:14556719

Appears in Networks:

p(HGNC:PSEN2, var("?")) increases a(CHEBI:"amyloid-beta") View Subject | View Object

Finally, some patients express mutant presenilin proteins 1 and 2 (PS1 and PS2) that can change the processing of APP by altering gamma secretase activity, thereby promoting the generation of amyloidogenic Abeta (Hardy and Selkoe, 2002). PubMed:14556719

Appears in Networks:

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.