complex(p(HBP:HBP00042, frag("?")), p(HGNC:TNFRSF21)) increases bp(GO:"neuron death")

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PubMed:22122372

A recent study suggested that sAPP-beta can be cleaved to generate an N-terminal fragment that is a ligand for death receptor 6, activating caspase 6 which further stimulates axonal pruning and neuronal cell death (Nikolaev et al. 2009)

Related Edges 1

• complex(p(HBP:HBP00042, frag("?")), p(HGNC:TNFRSF21)) increases bp(GO:"synapse pruning")

Confidence

High

MeSH

Neurons

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