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complex(p(HBP:HBP00042, frag("?")), p(HGNC:TNFRSF21))

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Components

Appears in Networks 1

Proteolytic processing of Alzeimer's beta-amyloid precursor protein v1.0.1

In-Edges 0

Out-Edges 4

complex(p(HBP:HBP00042, frag("?")), p(HGNC:TNFRSF21)) hasComponent p(HBP:HBP00042, frag("?")) View Subject | View Object

Appears in Networks:

complex(p(HBP:HBP00042, frag("?")), p(HGNC:TNFRSF21)) hasComponent p(HGNC:TNFRSF21) View Subject | View Object

Appears in Networks:

complex(p(HBP:HBP00042, frag("?")), p(HGNC:TNFRSF21)) increases bp(GO:"neuron death") View Subject | View Object

A recent study suggested that sAPP-beta can be cleaved to generate an N-terminal fragment that is a ligand for death receptor 6, activating caspase 6 which further stimulates axonal pruning and neuronal cell death (Nikolaev et al. 2009) PubMed:22122372

Appears in Networks:
Annotations
Confidence
High
MeSH
Neurons

complex(p(HBP:HBP00042, frag("?")), p(HGNC:TNFRSF21)) increases bp(GO:"synapse pruning") View Subject | View Object

A recent study suggested that sAPP-beta can be cleaved to generate an N-terminal fragment that is a ligand for death receptor 6, activating caspase 6 which further stimulates axonal pruning and neuronal cell death (Nikolaev et al. 2009) PubMed:22122372

Appears in Networks:
Annotations
Confidence
High
MeSH
Neurons

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.