p(MGI:Mapt, var("p.Pro301Leu")) increases p(MGI:Il1b)

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PubMed:30126037

Consistent with the transcriptomic profile in human NFT-bearing neurons and mouse brain tissue (Figure 1a-c), SASP genes were found to be upregulated in tauNFT brains, i.e., Il1b was 4- and 2-fold higher than CTL and tauWT, respectively; and Cxcl1 was 4-fold higher than both control genotypes; Tnfa was 13- and 8-fold higher than CTL and tauWT, respectively; Tlr4 was 3-fold higher than both control genotypes (Figure 2a-d)

Related Edges 3

• p(MGI:Mapt, var("p.Pro301Leu")) increases p(MGI:Cxcl1)
• p(MGI:Mapt, var("p.Pro301Leu")) increases p(MGI:Tnf)
• p(MGI:Mapt, var("p.Pro301Leu")) increases p(MGI:Tlr4)

Confidence

Medium

MeSH

Neurons

MeSH

Alzheimer Disease

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