a(CHEBI:heme) negativeCorrelation bp(MESH:Phagocytosis)
Induction of hemolysis with phenylhydrazine or addition of heme to whole blood at concentrations mimicking the physiological range of plasma heme in hemolytic patients (5–50 μM)6 led to a dose-dependent impairment of E. coli phagocytosis by neutrophils and monocytes, as compared with DMSO controls (Fig. 3g and Supplementary Fig. 2n,o), indicating that our mouse model was reflective of human hemolytic conditions.
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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.