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monocyte

Name
monocyte
Namespace Keyword
Cell
Namespace
Cell Ontology (CL)
Namespace Version
20170511
Namespace URL
https://arty.scai.fraunhofer.de/artifactory/bel/annotation/cell/cell-20170511.belanno

Sample Annotated Edges 5

a(CHEBI:heme) positiveCorrelation a(MESH:"Reactive Oxygen Species") View Subject | View Object

Heme is an amphipathic molecule that can promote the generation of reactive oxygen species (ROS) via Fenton chemistry, thereby leading to membrane damage. PubMed:27798618

Appears in Networks:
Annotations
Cell Ontology (CL)
monocyte
MeSH
Blood
MeSH
Sepsis
Text Location
Results

a(CHEBI:heme) negativeCorrelation bp(MESH:Phagocytosis) View Subject | View Object

Induction of hemolysis with phenylhydrazine or addition of heme to whole blood at concentrations mimicking the physiological range of plasma heme in hemolytic patients (5–50 μM)6 led to a dose-dependent impairment of E. coli phagocytosis by neutrophils and monocytes, as compared with DMSO controls (Fig. 3g and Supplementary Fig. 2n,o), indicating that our mouse model was reflective of human hemolytic conditions. PubMed:27798618

Appears in Networks:
Annotations
Cell Ontology (CL)
monocyte
MeSH
Blood
MeSH
Sepsis
Text Location
Results

a(CHEBI:heme) positiveCorrelation bp(GO:"actin cytoskeleton reorganization") View Subject | View Object

We quantified these changes by automatic image analysis and found that heme-induced cytoskeleton rearrangement led to a significant increase in cell area and perimeter, as well as a decrease in circularity (form factor) (Fig. 4d,e and Supplementary Fig. 3b–d), indicating that the heme-induced defective phagocytic response was likely tied to cytoskeleton rearrangements. PubMed:27798618

Appears in Networks:
Annotations
Cell Ontology (CL)
monocyte
MeSH
Blood
MeSH
Sepsis
Text Location
Results

a(CHEBI:heme) increases act(p(MGI:Cdc42)) View Subject | View Object

Heme stimulation of RAW264.7 macrophages induced immediate Cdc42 activation for up to 30 min after stimulation (Fig. 6d), without inducing changes in total Cdc42 protein amounts (Supplementary Fig. 6b). PubMed:27798618

Appears in Networks:
Annotations
Cell Ontology (CL)
monocyte
MeSH
Blood
MeSH
Sepsis
Text Location
Results

a(CHEBI:quinine) positiveCorrelation bp(MESH:Phagocytosis) View Subject | View Object

The top performing drug identified was the antimalarial compound quinine, which fully restored phagocytosis in the presence of heme, without affecting baseline phagocytosis (Fig. 8a and Supplementary Fig. 8b,c). PubMed:27798618

Appears in Networks:
Annotations
Cell Ontology (CL)
monocyte
MeSH
Blood
MeSH
Sepsis
Text Location
Results

Showing 5 of 35 edges

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.