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a(CHEBI:quinine)

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Entity

Name
quinine
Namespace
chebi
Namespace Version
20190224
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/c328ad964c08967a0417a887510b97b965a62fa5/external/chebi-names.belns

Appears in Networks 2

Activity-dependent neuroprotective protein (ADNP) is an alcohol-responsive gene and negative regulator of alcohol consumption in female mice v1.0.0

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 5

p(HGNC:ADNP, pmod(MESH:Haploinsufficiency)) causesNoChange tloc(a(CHEBI:quinine), fromLoc(GO:"extracellular space"), toLoc(GO:intracellular)) View Subject | View Object

As shown in Fig. 3e, f, we found no difference between genotypes in saccharin or quinine intake, suggesting that the effect of Adnp deficiency is specific to alcohol, and does not apply to sweet reinforcers or bitter-taste solutions PubMed:30008470

Appears in Networks:
Annotations
Gender
Female

bp(GO:"actin cytoskeleton reorganization") negativeCorrelation a(CHEBI:quinine) View Subject | View Object

Quinine pretreatment protected RAW264.7 macrophages (Fig. 8b and Supplementary Fig. 8c,d) and human macrophages (Fig. 8c) from heme-induced inhibition of phagocytosis and actin cytoskeleton changes (Supplementary Fig. 8e,f) compared with DMSO-treated cells. PubMed:27798618

Appears in Networks:
Annotations
Cell Ontology (CL)
monocyte
MeSH
Blood
MeSH
Sepsis
Text Location
Results

bp(MESH:"Bacterial Load") negativeCorrelation a(CHEBI:quinine) View Subject | View Object

Following induction of E. coli peritonitis in wild-type mice, quinine treatment did not affect plasma heme levels, but did lead to a reduction in bacterial counts in blood and liver (Fig. 8f,g and Supplementary Fig. 8g,h), thereby restoring the bacterial clearance capacity of heme-treated mice. PubMed:27798618

Appears in Networks:
Annotations
Cell Ontology (CL)
monocyte
MeSH
Blood
MeSH
Sepsis
Text Location
Results

bp(MESH:Phagocytosis) positiveCorrelation a(CHEBI:quinine) View Subject | View Object

The top performing drug identified was the antimalarial compound quinine, which fully restored phagocytosis in the presence of heme, without affecting baseline phagocytosis (Fig. 8a and Supplementary Fig. 8b,c). PubMed:27798618

Appears in Networks:
Annotations
Cell Ontology (CL)
monocyte
MeSH
Blood
MeSH
Sepsis
Text Location
Results

bp(MESH:Phagocytosis) positiveCorrelation a(CHEBI:quinine) View Subject | View Object

Quinine pretreatment protected RAW264.7 macrophages (Fig. 8b and Supplementary Fig. 8c,d) and human macrophages (Fig. 8c) from heme-induced inhibition of phagocytosis and actin cytoskeleton changes (Supplementary Fig. 8e,f) compared with DMSO-treated cells. PubMed:27798618

Appears in Networks:
Annotations
Cell Ontology (CL)
monocyte
MeSH
Blood
MeSH
Sepsis
Text Location
Results

Out-Edges 5

a(CHEBI:quinine) positiveCorrelation bp(MESH:Phagocytosis) View Subject | View Object

The top performing drug identified was the antimalarial compound quinine, which fully restored phagocytosis in the presence of heme, without affecting baseline phagocytosis (Fig. 8a and Supplementary Fig. 8b,c). PubMed:27798618

Appears in Networks:
Annotations
Cell Ontology (CL)
monocyte
MeSH
Blood
MeSH
Sepsis
Text Location
Results

a(CHEBI:quinine) positiveCorrelation bp(MESH:Phagocytosis) View Subject | View Object

Quinine pretreatment protected RAW264.7 macrophages (Fig. 8b and Supplementary Fig. 8c,d) and human macrophages (Fig. 8c) from heme-induced inhibition of phagocytosis and actin cytoskeleton changes (Supplementary Fig. 8e,f) compared with DMSO-treated cells. PubMed:27798618

Appears in Networks:
Annotations
Cell Ontology (CL)
monocyte
MeSH
Blood
MeSH
Sepsis
Text Location
Results

a(CHEBI:quinine) negativeCorrelation bp(GO:"actin cytoskeleton reorganization") View Subject | View Object

Quinine pretreatment protected RAW264.7 macrophages (Fig. 8b and Supplementary Fig. 8c,d) and human macrophages (Fig. 8c) from heme-induced inhibition of phagocytosis and actin cytoskeleton changes (Supplementary Fig. 8e,f) compared with DMSO-treated cells. PubMed:27798618

Appears in Networks:
Annotations
Cell Ontology (CL)
monocyte
MeSH
Blood
MeSH
Sepsis
Text Location
Results

a(CHEBI:quinine) decreases complex(a(CHEBI:heme), p(MGI:Dock8)) View Subject | View Object

Notably, quinine diminished the association of heme with DOCK8 without affecting the association of heme with MPP1 or LGALS3 in RAW264.7 macrophages (Fig. 8d), suggesting that quinine exerted its protective effect by specifically disrupting the heme-DOCK8 association. PubMed:27798618

Appears in Networks:
Annotations
Cell Ontology (CL)
monocyte
MeSH
Blood
MeSH
Sepsis
Text Location
Results

a(CHEBI:quinine) negativeCorrelation bp(MESH:"Bacterial Load") View Subject | View Object

Following induction of E. coli peritonitis in wild-type mice, quinine treatment did not affect plasma heme levels, but did lead to a reduction in bacterial counts in blood and liver (Fig. 8f,g and Supplementary Fig. 8g,h), thereby restoring the bacterial clearance capacity of heme-treated mice. PubMed:27798618

Appears in Networks:
Annotations
Cell Ontology (CL)
monocyte
MeSH
Blood
MeSH
Sepsis
Text Location
Results

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BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.