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bp(MESH:"Bacterial Load")

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Entity

Name
Bacterial Load
Namespace
MeSH
Namespace Version
20181007
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/01c9daa61012b37dd0a1bc962521ba51a15b38f1/external/mesh-names.belns

Appears in Networks 1

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 7

a(CHEBI:"desferrioxamine B") decreases bp(MESH:"Bacterial Load") View Subject | View Object

Chelation of growth-medium iron with deferoxamine (DFO, 10 μM) led to a reduction in bacterial growth, as compared with non-chelated controls (Fig. 2a). PubMed:27798618

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Plasma
MeSH
Sepsis
Text Location
Results

a(CHEBI:heme) positiveCorrelation bp(MESH:"Bacterial Load") View Subject | View Object

Following i.p. E. coli infection, we observed a significant increase in plasma heme levels in LysM-Cre+/−Hmox1fl/fl mice (Fig. 1e and Supplementary Fig. 1c), which was accompanied by increased bacterial numbers in blood and liver (Fig. 1f and Supplementary Fig. 1d) and impaired survival (Fig. 1g) when compared with LysM-Cre−/−Hmox1fl/fl controls. PubMed:27798618

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Plasma
Text Location
Results

a(CHEBI:heme) positiveCorrelation bp(MESH:"Bacterial Load") View Subject | View Object

Thus, enhanced levels of plasma heme, induced by either exogenous heme administration or a lack of HO-1 expression in macrophages, resulted in an increased susceptibility to E. coli sepsis. PubMed:27798618

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Plasma
MeSH
Sepsis
Text Location
Results

a(CHEBI:heme) positiveCorrelation bp(MESH:"Bacterial Load") View Subject | View Object

Plasma heme amounts were comparable in mice pretreated with Fe3+ or PBS (Fig. 2d), and despite the similarly increased availability of iron in both heme- and Fe3+-treated mice (Fig. 2e), only heme-treated mice presented a significantly higher bacterial burden in the blood and liver compared with PBS- or Fe3+-treated mice (Fig. 2f). PubMed:27798618

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Blood
MeSH
Sepsis
Text Location
Results

a(CHEBI:heme) positiveCorrelation bp(MESH:"Bacterial Load") View Subject | View Object

These results indicate that increased heme concentrations directly lead to increased bacterial counts during sepsis and that bacterial iron requirements are met via heme-independent mechanisms. PubMed:27798618

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Blood
MeSH
Sepsis
Text Location
Results

a(CHEBI:quinine) negativeCorrelation bp(MESH:"Bacterial Load") View Subject | View Object

Following induction of E. coli peritonitis in wild-type mice, quinine treatment did not affect plasma heme levels, but did lead to a reduction in bacterial counts in blood and liver (Fig. 8f,g and Supplementary Fig. 8g,h), thereby restoring the bacterial clearance capacity of heme-treated mice. PubMed:27798618

Appears in Networks:
Annotations
Cell Ontology (CL)
monocyte
MeSH
Blood
MeSH
Sepsis
Text Location
Results

a(HM:"stored erythrocytes") positiveCorrelation bp(MESH:"Bacterial Load") View Subject | View Object

Pulmonary edema approximately doubled (Fig 1D), and lung bacterial CFUs significantly increased (Fig 1E) in mice resuscitated with stored RBCs compared to those that received fresh RBCs. PubMed:29522519

Appears in Networks:
Annotations
Text Location
Results

Out-Edges 6

bp(MESH:"Bacterial Load") positiveCorrelation a(CHEBI:heme) View Subject | View Object

Following i.p. E. coli infection, we observed a significant increase in plasma heme levels in LysM-Cre+/−Hmox1fl/fl mice (Fig. 1e and Supplementary Fig. 1c), which was accompanied by increased bacterial numbers in blood and liver (Fig. 1f and Supplementary Fig. 1d) and impaired survival (Fig. 1g) when compared with LysM-Cre−/−Hmox1fl/fl controls. PubMed:27798618

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Plasma
Text Location
Results

bp(MESH:"Bacterial Load") positiveCorrelation a(CHEBI:heme) View Subject | View Object

Thus, enhanced levels of plasma heme, induced by either exogenous heme administration or a lack of HO-1 expression in macrophages, resulted in an increased susceptibility to E. coli sepsis. PubMed:27798618

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Plasma
MeSH
Sepsis
Text Location
Results

bp(MESH:"Bacterial Load") positiveCorrelation a(CHEBI:heme) View Subject | View Object

Plasma heme amounts were comparable in mice pretreated with Fe3+ or PBS (Fig. 2d), and despite the similarly increased availability of iron in both heme- and Fe3+-treated mice (Fig. 2e), only heme-treated mice presented a significantly higher bacterial burden in the blood and liver compared with PBS- or Fe3+-treated mice (Fig. 2f). PubMed:27798618

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Blood
MeSH
Sepsis
Text Location
Results

bp(MESH:"Bacterial Load") positiveCorrelation a(CHEBI:heme) View Subject | View Object

These results indicate that increased heme concentrations directly lead to increased bacterial counts during sepsis and that bacterial iron requirements are met via heme-independent mechanisms. PubMed:27798618

Appears in Networks:
Annotations
Cell Ontology (CL)
macrophage
MeSH
Blood
MeSH
Sepsis
Text Location
Results

bp(MESH:"Bacterial Load") negativeCorrelation a(CHEBI:quinine) View Subject | View Object

Following induction of E. coli peritonitis in wild-type mice, quinine treatment did not affect plasma heme levels, but did lead to a reduction in bacterial counts in blood and liver (Fig. 8f,g and Supplementary Fig. 8g,h), thereby restoring the bacterial clearance capacity of heme-treated mice. PubMed:27798618

Appears in Networks:
Annotations
Cell Ontology (CL)
monocyte
MeSH
Blood
MeSH
Sepsis
Text Location
Results

bp(MESH:"Bacterial Load") positiveCorrelation a(HM:"stored erythrocytes") View Subject | View Object

Pulmonary edema approximately doubled (Fig 1D), and lung bacterial CFUs significantly increased (Fig 1E) in mice resuscitated with stored RBCs compared to those that received fresh RBCs. PubMed:29522519

Appears in Networks:
Annotations
Text Location
Results

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.