complex(a(GO:lysosome), p(MGI:Lrrk2, var("?"))) decreases tloc(p(MGI:Lrrk2, var("?")), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome))

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PubMed:29024336

This is in clear contrast to other pathogenic proteins such as mutant alpha-synuclein or mutant LRRK2 that bind to lysosomes but fail to translocate through CMA (Cuervo et al., 2004; Orenstein et al., 2013)

Related Edges 1

• complex(a(GO:lysosome), p(MGI:Snca, var("?"))) decreases tloc(p(MGI:Snca, var("?")), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome))

MeSH

Lysosomes

Confidence

Medium

MeSH

Brain

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

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